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Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study

OBJECTIVE: To determine the association of overnight extubation (OE) with extubation success. STUDY DESIGN: Retrospective cohort study in three NICUs from 2016 to 2020. Infants without congenital anomalies, less than 1500 grams at birth, who were ventilated and received an extubation attempt were in...

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Autores principales: Guy, Brittany, Dye, Mary Eva, Richards, Laura, Guthrie, Scott O., Hatch, L. Dupree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308074/
https://www.ncbi.nlm.nih.gov/pubmed/34304243
http://dx.doi.org/10.1038/s41372-021-01168-6
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author Guy, Brittany
Dye, Mary Eva
Richards, Laura
Guthrie, Scott O.
Hatch, L. Dupree
author_facet Guy, Brittany
Dye, Mary Eva
Richards, Laura
Guthrie, Scott O.
Hatch, L. Dupree
author_sort Guy, Brittany
collection PubMed
description OBJECTIVE: To determine the association of overnight extubation (OE) with extubation success. STUDY DESIGN: Retrospective cohort study in three NICUs from 2016 to 2020. Infants without congenital anomalies, less than 1500 grams at birth, who were ventilated and received an extubation attempt were included. Primary exposure was OE (7:00 pm–6:59 am) and outcome was extubation success defined as no mechanical ventilation for at least 7 days after extubation. RESULTS: A total of 76/379 (20%) infants received OE. Infants extubated during the daytime were older and had higher illness severity markers. Extubation success rates did not differ for overnight (57/76, 75%) versus daytime extubations (231/303, 76%) after adjusting for confounders (adjusted relative risk 0.95, 95% CI 0.82–1.11). CONCLUSION: Though infants in our cohort undergoing daytime and OE were dissimilar, extubation success rates did not differ. Larger multicenter studies are needed to test our findings and identify markers of extubation readiness in preterm infants.
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spelling pubmed-83080742021-07-26 Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study Guy, Brittany Dye, Mary Eva Richards, Laura Guthrie, Scott O. Hatch, L. Dupree J Perinatol Article OBJECTIVE: To determine the association of overnight extubation (OE) with extubation success. STUDY DESIGN: Retrospective cohort study in three NICUs from 2016 to 2020. Infants without congenital anomalies, less than 1500 grams at birth, who were ventilated and received an extubation attempt were included. Primary exposure was OE (7:00 pm–6:59 am) and outcome was extubation success defined as no mechanical ventilation for at least 7 days after extubation. RESULTS: A total of 76/379 (20%) infants received OE. Infants extubated during the daytime were older and had higher illness severity markers. Extubation success rates did not differ for overnight (57/76, 75%) versus daytime extubations (231/303, 76%) after adjusting for confounders (adjusted relative risk 0.95, 95% CI 0.82–1.11). CONCLUSION: Though infants in our cohort undergoing daytime and OE were dissimilar, extubation success rates did not differ. Larger multicenter studies are needed to test our findings and identify markers of extubation readiness in preterm infants. Nature Publishing Group US 2021-07-24 2021 /pmc/articles/PMC8308074/ /pubmed/34304243 http://dx.doi.org/10.1038/s41372-021-01168-6 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Guy, Brittany
Dye, Mary Eva
Richards, Laura
Guthrie, Scott O.
Hatch, L. Dupree
Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title_full Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title_fullStr Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title_full_unstemmed Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title_short Association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
title_sort association of time of day and extubation success in very low birthweight infants: a multicenter cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308074/
https://www.ncbi.nlm.nih.gov/pubmed/34304243
http://dx.doi.org/10.1038/s41372-021-01168-6
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