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SIR Dynamics with Vaccination in a Large Configuration Model

We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the fra...

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Detalles Bibliográficos
Autores principales: Ferreyra, Emanuel Javier, Jonckheere, Matthieu, Pinasco, Juan Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308122/
https://www.ncbi.nlm.nih.gov/pubmed/34334841
http://dx.doi.org/10.1007/s00245-021-09810-7
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author Ferreyra, Emanuel Javier
Jonckheere, Matthieu
Pinasco, Juan Pablo
author_facet Ferreyra, Emanuel Javier
Jonckheere, Matthieu
Pinasco, Juan Pablo
author_sort Ferreyra, Emanuel Javier
collection PubMed
description We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the framework of game theory, both in the centralized and decentralized setting. We show how the characteristics of the graph (degree distribution) influence the vaccination efficiency for optimal strategies, and we compute the limiting final size of the epidemic depending on the degree distribution of the graph and the parameters of infection, recovery and vaccination. We also present several simulations for two types of vaccination, showing how the optimal controls allow to decrease the number of infections and underlining the crucial role of the network characteristics in the propagation of the disease and the vaccination program.
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spelling pubmed-83081222021-07-26 SIR Dynamics with Vaccination in a Large Configuration Model Ferreyra, Emanuel Javier Jonckheere, Matthieu Pinasco, Juan Pablo Appl Math Optim Article We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the framework of game theory, both in the centralized and decentralized setting. We show how the characteristics of the graph (degree distribution) influence the vaccination efficiency for optimal strategies, and we compute the limiting final size of the epidemic depending on the degree distribution of the graph and the parameters of infection, recovery and vaccination. We also present several simulations for two types of vaccination, showing how the optimal controls allow to decrease the number of infections and underlining the crucial role of the network characteristics in the propagation of the disease and the vaccination program. Springer US 2021-07-24 2021 /pmc/articles/PMC8308122/ /pubmed/34334841 http://dx.doi.org/10.1007/s00245-021-09810-7 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ferreyra, Emanuel Javier
Jonckheere, Matthieu
Pinasco, Juan Pablo
SIR Dynamics with Vaccination in a Large Configuration Model
title SIR Dynamics with Vaccination in a Large Configuration Model
title_full SIR Dynamics with Vaccination in a Large Configuration Model
title_fullStr SIR Dynamics with Vaccination in a Large Configuration Model
title_full_unstemmed SIR Dynamics with Vaccination in a Large Configuration Model
title_short SIR Dynamics with Vaccination in a Large Configuration Model
title_sort sir dynamics with vaccination in a large configuration model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308122/
https://www.ncbi.nlm.nih.gov/pubmed/34334841
http://dx.doi.org/10.1007/s00245-021-09810-7
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