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SIR Dynamics with Vaccination in a Large Configuration Model
We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the fra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308122/ https://www.ncbi.nlm.nih.gov/pubmed/34334841 http://dx.doi.org/10.1007/s00245-021-09810-7 |
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author | Ferreyra, Emanuel Javier Jonckheere, Matthieu Pinasco, Juan Pablo |
author_facet | Ferreyra, Emanuel Javier Jonckheere, Matthieu Pinasco, Juan Pablo |
author_sort | Ferreyra, Emanuel Javier |
collection | PubMed |
description | We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the framework of game theory, both in the centralized and decentralized setting. We show how the characteristics of the graph (degree distribution) influence the vaccination efficiency for optimal strategies, and we compute the limiting final size of the epidemic depending on the degree distribution of the graph and the parameters of infection, recovery and vaccination. We also present several simulations for two types of vaccination, showing how the optimal controls allow to decrease the number of infections and underlining the crucial role of the network characteristics in the propagation of the disease and the vaccination program. |
format | Online Article Text |
id | pubmed-8308122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-83081222021-07-26 SIR Dynamics with Vaccination in a Large Configuration Model Ferreyra, Emanuel Javier Jonckheere, Matthieu Pinasco, Juan Pablo Appl Math Optim Article We consider an SIR model with vaccination strategy on a sparse configuration model random graph. We show the convergence of the system when the number of nodes grows and characterize the scaling limits. Then, we prove the existence of optimal controls for the limiting equations formulated in the framework of game theory, both in the centralized and decentralized setting. We show how the characteristics of the graph (degree distribution) influence the vaccination efficiency for optimal strategies, and we compute the limiting final size of the epidemic depending on the degree distribution of the graph and the parameters of infection, recovery and vaccination. We also present several simulations for two types of vaccination, showing how the optimal controls allow to decrease the number of infections and underlining the crucial role of the network characteristics in the propagation of the disease and the vaccination program. Springer US 2021-07-24 2021 /pmc/articles/PMC8308122/ /pubmed/34334841 http://dx.doi.org/10.1007/s00245-021-09810-7 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Ferreyra, Emanuel Javier Jonckheere, Matthieu Pinasco, Juan Pablo SIR Dynamics with Vaccination in a Large Configuration Model |
title | SIR Dynamics with Vaccination in a Large Configuration Model |
title_full | SIR Dynamics with Vaccination in a Large Configuration Model |
title_fullStr | SIR Dynamics with Vaccination in a Large Configuration Model |
title_full_unstemmed | SIR Dynamics with Vaccination in a Large Configuration Model |
title_short | SIR Dynamics with Vaccination in a Large Configuration Model |
title_sort | sir dynamics with vaccination in a large configuration model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308122/ https://www.ncbi.nlm.nih.gov/pubmed/34334841 http://dx.doi.org/10.1007/s00245-021-09810-7 |
work_keys_str_mv | AT ferreyraemanueljavier sirdynamicswithvaccinationinalargeconfigurationmodel AT jonckheerematthieu sirdynamicswithvaccinationinalargeconfigurationmodel AT pinascojuanpablo sirdynamicswithvaccinationinalargeconfigurationmodel |