Cargando…

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy

FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological function. Many studies have found that FAK is overexpressed in many human cancer cell lines, which promotes tumor cell growth by controlling cell adhesion, migration, proliferation, and survival. Therefore, target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pang, Xiao-Jing, Liu, Xiu-Juan, Liu, Yuan, Liu, Wen-Bo, Li, Yin-Ru, Yu, Guang-Xi, Tian, Xin-Yi, Zhang, Yan-Bing, Song, Jian, Jin, Cheng-Yun, Zhang, Sai-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308130/ https://www.ncbi.nlm.nih.gov/pubmed/34299525 http://dx.doi.org/10.3390/molecules26144250

Ejemplares similares

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling
por: Zhang, Baoyuan, et al.
Publicado: (2021)

Focal adhesion kinase (FAK) expression and activation during lens development
por: Kokkinos, Maria I., et al.
Publicado: (2007)

Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis
por: Rama, Ramya, et al.
Publicado: (2022)

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions
Publicado: (1993)

Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart
por: Hirth, Sofia, et al.
Publicado: (2016)

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
por: Zhou, Jin, et al.
Publicado: (2019)

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis
por: Golubovskaya, Vita M, et al.
Publicado: (2009)

Caspase-mediated Cleavage of Focal Adhesion Kinase pp125(FAK) and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis
por: Levkau, Bodo, et al.
Publicado: (1998)

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)
por: Woo, Jong Kyu, et al.
Publicado: (2017)

SAT-574 Elucidating the Role of Nuclear Focal Adhesion Kinase (FAK) in Thyroid Cancer
por: Kellett, Meghan, et al.
Publicado: (2019)

Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma
por: Francalanci, Paola, et al.
Publicado: (2020)

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice
por: Alexopoulou, Annika N, et al.
Publicado: (2017)

ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain
por: Rashmi,, et al.
Publicado: (2021)

Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling
por: Dwyer, Sheila Figel, et al.
Publicado: (2015)

Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis
por: Zeng, Xiao-Qing, et al.
Publicado: (2016)

FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis
por: Antoniades, Ioanna, et al.
Publicado: (2021)

Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles
por: Hamadi, Abdelkader, et al.
Publicado: (2010)

Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics
por: Tomar, Alok, et al.
Publicado: (2012)

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells
por: Hu, Ying-Li, et al.
Publicado: (2014)

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
por: Tapial Martínez, Paula, et al.
Publicado: (2020)

MiR-7a is an important mediator in Fas-associated protein with death domain (FADD)-regulated expression of focal adhesion kinase (FAK)
por: Liu, Yingting, et al.
Publicado: (2016)

Molecular dynamics simulation analysis of Focal Adhesive Kinase (FAK) docked with solanesol as an anti-cancer agent
por: Daneial, Betty, et al.
Publicado: (2017)

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
por: Rigiracciolo, Damiano Cosimo, et al.
Publicado: (2019)

Direct association of pp125FAK with paxillin, the focal adhesion- targeting mechanism of pp125FAK
Publicado: (1995)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

β1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival
por: Santos, Andrea Rachelle C., et al.
Publicado: (2012)

Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion
por: Heuslein, Joshua L., et al.
Publicado: (2016)

Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity
por: Kishi, Takayuki, et al.
Publicado: (2016)

Activation of the integrins α5β1 and αvβ3 and focal adhesion kinase (FAK) during arteriogenesis
por: Cai, Wei-Jun, et al.
Publicado: (2008)

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes
por: Choi, Yun-Hee, et al.
Publicado: (2015)

pH sensing by FAK-His58 regulates focal adhesion remodeling
por: Choi, Chang-Hoon, et al.
Publicado: (2013)

Phagocyte Transcriptomic Analysis Reveals Focal Adhesion Kinase (FAK) and Heparan Sulfate Proteoglycans (HSPGs) as Major Regulators in Anti-bacterial Defense of Crassostrea hongkongensis
por: Lin, Yue, et al.
Publicado: (2020)

Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway
por: Huang, Tao, et al.
Publicado: (2022)

The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion
por: Xu, Qiuping, et al.
Publicado: (2021)

Focal Adhesion Kinase (FAK) Mediates the Induction of Pro-Oncogenic and Fibrogenic Phenotypes in Hepatitis C Virus (HCV)-Infected Cells
por: Alisi, Anna, et al.
Publicado: (2012)

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
por: Chan, Keefe T., et al.
Publicado: (2009)

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
por: Zhou, Dennis W., et al.
Publicado: (2021)

Preparation, in vitro and in vivo evaluation, and molecular dynamics (MD) simulation studies of novel F-18 labeled tumor imaging agents targeting focal adhesion kinase (FAK)
por: Fang, Yu, et al.
Publicado: (2018)

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
por: Wu, Jui-Chung, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ini4nc5ukbifqgsob4imrn7efs