Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis

The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TP...

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Autores principales: Pavanelli, André L. S., Máximo, Leandro N. C., da Silva, Roberto S., Borissevitch, Iouri E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308150/
https://www.ncbi.nlm.nih.gov/pubmed/34202308
http://dx.doi.org/10.3390/nano11071674
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author Pavanelli, André L. S.
Máximo, Leandro N. C.
da Silva, Roberto S.
Borissevitch, Iouri E.
author_facet Pavanelli, André L. S.
Máximo, Leandro N. C.
da Silva, Roberto S.
Borissevitch, Iouri E.
author_sort Pavanelli, André L. S.
collection PubMed
description The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TPPS(4)), was studied in function of pH using the steady-state and time resolved optical absorption and fluorescence spectroscopies. It was shown that, depending on the charge state of the components, interaction with albumin could either prevent the formation of the QD…PPh complex, form a mixed QD…PPh…BSA complex or not affect PPh complexation with QD at all. The obtained results may be of interest for application in photomedicine.
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spelling pubmed-83081502021-07-25 Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis Pavanelli, André L. S. Máximo, Leandro N. C. da Silva, Roberto S. Borissevitch, Iouri E. Nanomaterials (Basel) Article The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged meso-tetra methyl pyridyl porphyrin (TMPyP) and negatively charged meso-tetrakis(p-sulfonato-phenyl) porphyrin (TPPS(4)), was studied in function of pH using the steady-state and time resolved optical absorption and fluorescence spectroscopies. It was shown that, depending on the charge state of the components, interaction with albumin could either prevent the formation of the QD…PPh complex, form a mixed QD…PPh…BSA complex or not affect PPh complexation with QD at all. The obtained results may be of interest for application in photomedicine. MDPI 2021-06-25 /pmc/articles/PMC8308150/ /pubmed/34202308 http://dx.doi.org/10.3390/nano11071674 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pavanelli, André L. S.
Máximo, Leandro N. C.
da Silva, Roberto S.
Borissevitch, Iouri E.
Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title_full Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title_fullStr Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title_full_unstemmed Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title_short Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis
title_sort effect of serum albumin on porphyrin-quantum dot complex formation, characteristics and spectroscopic analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308150/
https://www.ncbi.nlm.nih.gov/pubmed/34202308
http://dx.doi.org/10.3390/nano11071674
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