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Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a severe health threat. The COVID-19 infections occurring in humans and animals render human-animal interfaces hot spots for spreading the pandemic. Lessons from the past point towards the antiviral properties of copper formula...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308209/ https://www.ncbi.nlm.nih.gov/pubmed/34361206 http://dx.doi.org/10.3390/nano11071820 |
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author | Mosselhy, Dina A. Kareinen, Lauri Kivistö, Ilkka Aaltonen, Kirsi Virtanen, Jenni Ge, Yanling Sironen, Tarja |
author_facet | Mosselhy, Dina A. Kareinen, Lauri Kivistö, Ilkka Aaltonen, Kirsi Virtanen, Jenni Ge, Yanling Sironen, Tarja |
author_sort | Mosselhy, Dina A. |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a severe health threat. The COVID-19 infections occurring in humans and animals render human-animal interfaces hot spots for spreading the pandemic. Lessons from the past point towards the antiviral properties of copper formulations; however, data showing the “contact-time limit” surface inhibitory efficacy of copper formulations to contain SARS-CoV-2 are limited. Here, we show the rapid inhibition of SARS-CoV-2 after only 1 and 5 min on two different surfaces containing copper-silver (Cu-Ag) nanohybrids. We characterized the nanohybrids’ powder and surfaces using a series of sophisticated microscopy tools, including transmission and scanning electron microscopes (TEM and SEM) and energy-dispersive X-ray spectroscopy (EDX). We used culturing methods to demonstrate that Cu-Ag nanohybrids with high amounts of Cu (~65 and 78 wt%) and lower amounts of Ag (~7 and 9 wt%) inhibited SARS-CoV-2 efficiently. Collectively, the present work reveals the rapid SARS-CoV-2 surface inhibition and the promising application of such surfaces to break the SARS-CoV-2 transmission chain. For example, such applications could be invaluable within a hospital or live-stock settings, or any public place with surfaces that people frequently touch (i.e., public transportation, shopping malls, elevators, and door handles) after the precise control of different parameters and toxicity evaluations. |
format | Online Article Text |
id | pubmed-8308209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83082092021-07-25 Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces Mosselhy, Dina A. Kareinen, Lauri Kivistö, Ilkka Aaltonen, Kirsi Virtanen, Jenni Ge, Yanling Sironen, Tarja Nanomaterials (Basel) Article The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a severe health threat. The COVID-19 infections occurring in humans and animals render human-animal interfaces hot spots for spreading the pandemic. Lessons from the past point towards the antiviral properties of copper formulations; however, data showing the “contact-time limit” surface inhibitory efficacy of copper formulations to contain SARS-CoV-2 are limited. Here, we show the rapid inhibition of SARS-CoV-2 after only 1 and 5 min on two different surfaces containing copper-silver (Cu-Ag) nanohybrids. We characterized the nanohybrids’ powder and surfaces using a series of sophisticated microscopy tools, including transmission and scanning electron microscopes (TEM and SEM) and energy-dispersive X-ray spectroscopy (EDX). We used culturing methods to demonstrate that Cu-Ag nanohybrids with high amounts of Cu (~65 and 78 wt%) and lower amounts of Ag (~7 and 9 wt%) inhibited SARS-CoV-2 efficiently. Collectively, the present work reveals the rapid SARS-CoV-2 surface inhibition and the promising application of such surfaces to break the SARS-CoV-2 transmission chain. For example, such applications could be invaluable within a hospital or live-stock settings, or any public place with surfaces that people frequently touch (i.e., public transportation, shopping malls, elevators, and door handles) after the precise control of different parameters and toxicity evaluations. MDPI 2021-07-13 /pmc/articles/PMC8308209/ /pubmed/34361206 http://dx.doi.org/10.3390/nano11071820 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mosselhy, Dina A. Kareinen, Lauri Kivistö, Ilkka Aaltonen, Kirsi Virtanen, Jenni Ge, Yanling Sironen, Tarja Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title | Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title_full | Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title_fullStr | Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title_full_unstemmed | Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title_short | Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory Surfaces |
title_sort | copper-silver nanohybrids: sars-cov-2 inhibitory surfaces |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308209/ https://www.ncbi.nlm.nih.gov/pubmed/34361206 http://dx.doi.org/10.3390/nano11071820 |
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