Cargando…
The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal f...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308226/ https://www.ncbi.nlm.nih.gov/pubmed/34210046 http://dx.doi.org/10.3390/nu13072245 |
_version_ | 1783728230467895296 |
---|---|
author | Zanoaga, Oana Braicu, Cornelia Chiroi, Paul Andreea, Nutu Hajjar, Nadim Al Mărgărit, Simona Korban, Schuyler S. Berindan-Neagoe, Ioana |
author_facet | Zanoaga, Oana Braicu, Cornelia Chiroi, Paul Andreea, Nutu Hajjar, Nadim Al Mărgărit, Simona Korban, Schuyler S. Berindan-Neagoe, Ioana |
author_sort | Zanoaga, Oana |
collection | PubMed |
description | Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes. |
format | Online Article Text |
id | pubmed-8308226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83082262021-07-25 The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation Zanoaga, Oana Braicu, Cornelia Chiroi, Paul Andreea, Nutu Hajjar, Nadim Al Mărgărit, Simona Korban, Schuyler S. Berindan-Neagoe, Ioana Nutrients Review Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes. MDPI 2021-06-29 /pmc/articles/PMC8308226/ /pubmed/34210046 http://dx.doi.org/10.3390/nu13072245 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zanoaga, Oana Braicu, Cornelia Chiroi, Paul Andreea, Nutu Hajjar, Nadim Al Mărgărit, Simona Korban, Schuyler S. Berindan-Neagoe, Ioana The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title | The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title_full | The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title_fullStr | The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title_full_unstemmed | The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title_short | The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation |
title_sort | role of mir-155 in nutrition: modulating cancer-associated inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308226/ https://www.ncbi.nlm.nih.gov/pubmed/34210046 http://dx.doi.org/10.3390/nu13072245 |
work_keys_str_mv | AT zanoagaoana theroleofmir155innutritionmodulatingcancerassociatedinflammation AT braicucornelia theroleofmir155innutritionmodulatingcancerassociatedinflammation AT chiroipaul theroleofmir155innutritionmodulatingcancerassociatedinflammation AT andreeanutu theroleofmir155innutritionmodulatingcancerassociatedinflammation AT hajjarnadimal theroleofmir155innutritionmodulatingcancerassociatedinflammation AT margaritsimona theroleofmir155innutritionmodulatingcancerassociatedinflammation AT korbanschuylers theroleofmir155innutritionmodulatingcancerassociatedinflammation AT berindanneagoeioana theroleofmir155innutritionmodulatingcancerassociatedinflammation AT zanoagaoana roleofmir155innutritionmodulatingcancerassociatedinflammation AT braicucornelia roleofmir155innutritionmodulatingcancerassociatedinflammation AT chiroipaul roleofmir155innutritionmodulatingcancerassociatedinflammation AT andreeanutu roleofmir155innutritionmodulatingcancerassociatedinflammation AT hajjarnadimal roleofmir155innutritionmodulatingcancerassociatedinflammation AT margaritsimona roleofmir155innutritionmodulatingcancerassociatedinflammation AT korbanschuylers roleofmir155innutritionmodulatingcancerassociatedinflammation AT berindanneagoeioana roleofmir155innutritionmodulatingcancerassociatedinflammation |