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The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation

Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal f...

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Autores principales: Zanoaga, Oana, Braicu, Cornelia, Chiroi, Paul, Andreea, Nutu, Hajjar, Nadim Al, Mărgărit, Simona, Korban, Schuyler S., Berindan-Neagoe, Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308226/
https://www.ncbi.nlm.nih.gov/pubmed/34210046
http://dx.doi.org/10.3390/nu13072245
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author Zanoaga, Oana
Braicu, Cornelia
Chiroi, Paul
Andreea, Nutu
Hajjar, Nadim Al
Mărgărit, Simona
Korban, Schuyler S.
Berindan-Neagoe, Ioana
author_facet Zanoaga, Oana
Braicu, Cornelia
Chiroi, Paul
Andreea, Nutu
Hajjar, Nadim Al
Mărgărit, Simona
Korban, Schuyler S.
Berindan-Neagoe, Ioana
author_sort Zanoaga, Oana
collection PubMed
description Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes.
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spelling pubmed-83082262021-07-25 The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation Zanoaga, Oana Braicu, Cornelia Chiroi, Paul Andreea, Nutu Hajjar, Nadim Al Mărgărit, Simona Korban, Schuyler S. Berindan-Neagoe, Ioana Nutrients Review Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes. MDPI 2021-06-29 /pmc/articles/PMC8308226/ /pubmed/34210046 http://dx.doi.org/10.3390/nu13072245 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zanoaga, Oana
Braicu, Cornelia
Chiroi, Paul
Andreea, Nutu
Hajjar, Nadim Al
Mărgărit, Simona
Korban, Schuyler S.
Berindan-Neagoe, Ioana
The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title_full The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title_fullStr The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title_full_unstemmed The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title_short The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation
title_sort role of mir-155 in nutrition: modulating cancer-associated inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308226/
https://www.ncbi.nlm.nih.gov/pubmed/34210046
http://dx.doi.org/10.3390/nu13072245
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