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Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis

The effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications...

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Autores principales: Fernández-Candela, Alba, Calero, Alicia, Sánchez-Guillén, Luís, Escrig-Sos, Javier, Barreras, José A., López-Rodríguez-Arias, Francisco, Armañanzas, Laura, Murcia, Ana, Arroyo, Antonio, Lacueva, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308234/
https://www.ncbi.nlm.nih.gov/pubmed/34201458
http://dx.doi.org/10.3390/nu13072147
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author Fernández-Candela, Alba
Calero, Alicia
Sánchez-Guillén, Luís
Escrig-Sos, Javier
Barreras, José A.
López-Rodríguez-Arias, Francisco
Armañanzas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
author_facet Fernández-Candela, Alba
Calero, Alicia
Sánchez-Guillén, Luís
Escrig-Sos, Javier
Barreras, José A.
López-Rodríguez-Arias, Francisco
Armañanzas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
author_sort Fernández-Candela, Alba
collection PubMed
description The effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications was also analyzed. Patients treated within a peritoneal carcinomatosis program in which a complete or optimal cytoreduction was achieved were retrospectively analyzed. They were divided into two groups based on whether preoperative immunonutrition (IMN) or not (non-IMN) were administered. Clinical and surgical variables and postoperative complications were gathered. Predictive values of major morbidity of CRP during the first 3 postoperative days (POD) were also evaluated. A total of 107 patients were included, 48 belonging to the IMN group and 59 to the non-IMN group. In multivariate analysis immunonutrition (OR 0.247; 95%CI 0.071–0.859; p = 0.028), and the number of visceral resections (OR 1.947; 95%CI 1.086–3.488; p = 0.025) emerged as independent factors associated with postoperative major morbidity. CRP values above 103 mg/L yielded a negative predictive value of 84%. Preoperative intake of immunonutrition was associated with a decrease of postoperative major morbidity and might be recommended to patients with peritoneal carcinomatosis following CRS. Measuring CRP levels during the 3 first postoperative days is useful to rule out major morbidity.
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spelling pubmed-83082342021-07-25 Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis Fernández-Candela, Alba Calero, Alicia Sánchez-Guillén, Luís Escrig-Sos, Javier Barreras, José A. López-Rodríguez-Arias, Francisco Armañanzas, Laura Murcia, Ana Arroyo, Antonio Lacueva, Francisco Javier Nutrients Article The effect of preoperative immunonutrition intake on postoperative major complications in patients following cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) was assessed. The accuracy of C-Reactive Protein (CRP) for detecting postoperative complications was also analyzed. Patients treated within a peritoneal carcinomatosis program in which a complete or optimal cytoreduction was achieved were retrospectively analyzed. They were divided into two groups based on whether preoperative immunonutrition (IMN) or not (non-IMN) were administered. Clinical and surgical variables and postoperative complications were gathered. Predictive values of major morbidity of CRP during the first 3 postoperative days (POD) were also evaluated. A total of 107 patients were included, 48 belonging to the IMN group and 59 to the non-IMN group. In multivariate analysis immunonutrition (OR 0.247; 95%CI 0.071–0.859; p = 0.028), and the number of visceral resections (OR 1.947; 95%CI 1.086–3.488; p = 0.025) emerged as independent factors associated with postoperative major morbidity. CRP values above 103 mg/L yielded a negative predictive value of 84%. Preoperative intake of immunonutrition was associated with a decrease of postoperative major morbidity and might be recommended to patients with peritoneal carcinomatosis following CRS. Measuring CRP levels during the 3 first postoperative days is useful to rule out major morbidity. MDPI 2021-06-23 /pmc/articles/PMC8308234/ /pubmed/34201458 http://dx.doi.org/10.3390/nu13072147 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernández-Candela, Alba
Calero, Alicia
Sánchez-Guillén, Luís
Escrig-Sos, Javier
Barreras, José A.
López-Rodríguez-Arias, Francisco
Armañanzas, Laura
Murcia, Ana
Arroyo, Antonio
Lacueva, Francisco Javier
Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_full Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_fullStr Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_full_unstemmed Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_short Effect of Preoperative Immunonutrition on Postoperative Major Morbidity after Cytoreductive Surgery and HIPEC in Patients with Peritoneal Metastasis
title_sort effect of preoperative immunonutrition on postoperative major morbidity after cytoreductive surgery and hipec in patients with peritoneal metastasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308234/
https://www.ncbi.nlm.nih.gov/pubmed/34201458
http://dx.doi.org/10.3390/nu13072147
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