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Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients

(1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D statu...

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Autores principales: Zelzer, Sieglinde, Prüller, Florian, Curcic, Pero, Sloup, Zdenka, Holter, Magdalena, Herrmann, Markus, Mangge, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308267/
https://www.ncbi.nlm.nih.gov/pubmed/34206219
http://dx.doi.org/10.3390/nu13072129
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author Zelzer, Sieglinde
Prüller, Florian
Curcic, Pero
Sloup, Zdenka
Holter, Magdalena
Herrmann, Markus
Mangge, Harald
author_facet Zelzer, Sieglinde
Prüller, Florian
Curcic, Pero
Sloup, Zdenka
Holter, Magdalena
Herrmann, Markus
Mangge, Harald
author_sort Zelzer, Sieglinde
collection PubMed
description (1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D(3), 25(OH)D(2), 24,25(OH)(2)D(3), and 25,26(OH)(2)D(3) were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19.
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spelling pubmed-83082672021-07-25 Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients Zelzer, Sieglinde Prüller, Florian Curcic, Pero Sloup, Zdenka Holter, Magdalena Herrmann, Markus Mangge, Harald Nutrients Article (1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D(3), 25(OH)D(2), 24,25(OH)(2)D(3), and 25,26(OH)(2)D(3) were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19. MDPI 2021-06-22 /pmc/articles/PMC8308267/ /pubmed/34206219 http://dx.doi.org/10.3390/nu13072129 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zelzer, Sieglinde
Prüller, Florian
Curcic, Pero
Sloup, Zdenka
Holter, Magdalena
Herrmann, Markus
Mangge, Harald
Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title_full Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title_fullStr Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title_full_unstemmed Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title_short Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients
title_sort vitamin d metabolites and clinical outcome in hospitalized covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308267/
https://www.ncbi.nlm.nih.gov/pubmed/34206219
http://dx.doi.org/10.3390/nu13072129
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