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Up-Regulation of Specific Bioactive Lipids in Celiac Disease

Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. We engage in a metabolomic study that analyzes plasma metabolome in 17 children...

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Autores principales: Martín-Masot, Rafael, Galo-Licona, Jose Daniel, Mota-Martorell, Natàlia, Sol, Joaquim, Jové, Mariona, Maldonado, José, Pamplona, Reinald, Nestares, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308317/
https://www.ncbi.nlm.nih.gov/pubmed/34209150
http://dx.doi.org/10.3390/nu13072271
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author Martín-Masot, Rafael
Galo-Licona, Jose Daniel
Mota-Martorell, Natàlia
Sol, Joaquim
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
author_facet Martín-Masot, Rafael
Galo-Licona, Jose Daniel
Mota-Martorell, Natàlia
Sol, Joaquim
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
author_sort Martín-Masot, Rafael
collection PubMed
description Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. We engage in a metabolomic study that analyzes plasma metabolome in 17 children with CD treated with a gluten-free diet and 17 healthy control siblings in order to recognize potential changes in metabolic networks. Our data demonstrates the persistence of metabolic defects in CD subjects in spite of the dietary treatment, affecting a minor but significant fraction (around 4%, 209 out of 4893 molecular features) of the analyzed plasma metabolome. The affected molecular species are mainly, but not exclusively, lipid species with a particular affectation of steroids and derivatives (indicating an adrenal gland affectation), glycerophospholipids (to highlight phosphatidic acid), glycerolipids (with a special affectation of diacylglycerols), and fatty acyls (eicosanoids). Our findings are suggestive of an activation of the diacylglycerol-phosphatidic acid signaling pathway in CD that may potentially have detrimental effects via activation of several targets including protein kinases such as mTOR, which could be the basis of the morbidity and mortality connected with untreated CD. However, more studies are necessary to validate this idea regarding CD.
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spelling pubmed-83083172021-07-25 Up-Regulation of Specific Bioactive Lipids in Celiac Disease Martín-Masot, Rafael Galo-Licona, Jose Daniel Mota-Martorell, Natàlia Sol, Joaquim Jové, Mariona Maldonado, José Pamplona, Reinald Nestares, Teresa Nutrients Article Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome of CD subjects have been documented. We engage in a metabolomic study that analyzes plasma metabolome in 17 children with CD treated with a gluten-free diet and 17 healthy control siblings in order to recognize potential changes in metabolic networks. Our data demonstrates the persistence of metabolic defects in CD subjects in spite of the dietary treatment, affecting a minor but significant fraction (around 4%, 209 out of 4893 molecular features) of the analyzed plasma metabolome. The affected molecular species are mainly, but not exclusively, lipid species with a particular affectation of steroids and derivatives (indicating an adrenal gland affectation), glycerophospholipids (to highlight phosphatidic acid), glycerolipids (with a special affectation of diacylglycerols), and fatty acyls (eicosanoids). Our findings are suggestive of an activation of the diacylglycerol-phosphatidic acid signaling pathway in CD that may potentially have detrimental effects via activation of several targets including protein kinases such as mTOR, which could be the basis of the morbidity and mortality connected with untreated CD. However, more studies are necessary to validate this idea regarding CD. MDPI 2021-06-30 /pmc/articles/PMC8308317/ /pubmed/34209150 http://dx.doi.org/10.3390/nu13072271 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martín-Masot, Rafael
Galo-Licona, Jose Daniel
Mota-Martorell, Natàlia
Sol, Joaquim
Jové, Mariona
Maldonado, José
Pamplona, Reinald
Nestares, Teresa
Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title_full Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title_fullStr Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title_full_unstemmed Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title_short Up-Regulation of Specific Bioactive Lipids in Celiac Disease
title_sort up-regulation of specific bioactive lipids in celiac disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308317/
https://www.ncbi.nlm.nih.gov/pubmed/34209150
http://dx.doi.org/10.3390/nu13072271
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