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Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy

A magnetic nanocomposite, consisting of Fe(3)O(4) nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the...

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Autores principales: Simeonidis, Konstantinos, Kaprara, Efthimia, Rivera-Gil, Pilar, Xu, Ruixue, Teran, Francisco J., Kokkinos, Evgenios, Mitropoulos, Athanassios, Maniotis, Nikolaos, Balcells, Lluis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308439/
https://www.ncbi.nlm.nih.gov/pubmed/34361181
http://dx.doi.org/10.3390/nano11071796
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author Simeonidis, Konstantinos
Kaprara, Efthimia
Rivera-Gil, Pilar
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
author_facet Simeonidis, Konstantinos
Kaprara, Efthimia
Rivera-Gil, Pilar
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
author_sort Simeonidis, Konstantinos
collection PubMed
description A magnetic nanocomposite, consisting of Fe(3)O(4) nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe(2+), Fe(3+)) and Mg(2+)/Al(3+) nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe(3)O(4)/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.
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spelling pubmed-83084392021-07-25 Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy Simeonidis, Konstantinos Kaprara, Efthimia Rivera-Gil, Pilar Xu, Ruixue Teran, Francisco J. Kokkinos, Evgenios Mitropoulos, Athanassios Maniotis, Nikolaos Balcells, Lluis Nanomaterials (Basel) Article A magnetic nanocomposite, consisting of Fe(3)O(4) nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe(2+), Fe(3+)) and Mg(2+)/Al(3+) nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe(3)O(4)/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays. MDPI 2021-07-09 /pmc/articles/PMC8308439/ /pubmed/34361181 http://dx.doi.org/10.3390/nano11071796 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Simeonidis, Konstantinos
Kaprara, Efthimia
Rivera-Gil, Pilar
Xu, Ruixue
Teran, Francisco J.
Kokkinos, Evgenios
Mitropoulos, Athanassios
Maniotis, Nikolaos
Balcells, Lluis
Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title_full Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title_fullStr Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title_full_unstemmed Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title_short Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
title_sort hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308439/
https://www.ncbi.nlm.nih.gov/pubmed/34361181
http://dx.doi.org/10.3390/nano11071796
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