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Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study

Coffee consumption has been linked to a lower risk of cardiovascular disease in observational studies, but whether the associations are causal is not known. We conducted a Mendelian randomization investigation to assess the potential causal role of coffee consumption in cardiovascular disease. Twelv...

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Autores principales: Yuan, Shuai, Carter, Paul, Mason, Amy M., Burgess, Stephen, Larsson, Susanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308456/
https://www.ncbi.nlm.nih.gov/pubmed/34203356
http://dx.doi.org/10.3390/nu13072218
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author Yuan, Shuai
Carter, Paul
Mason, Amy M.
Burgess, Stephen
Larsson, Susanna C.
author_facet Yuan, Shuai
Carter, Paul
Mason, Amy M.
Burgess, Stephen
Larsson, Susanna C.
author_sort Yuan, Shuai
collection PubMed
description Coffee consumption has been linked to a lower risk of cardiovascular disease in observational studies, but whether the associations are causal is not known. We conducted a Mendelian randomization investigation to assess the potential causal role of coffee consumption in cardiovascular disease. Twelve independent genetic variants were used to proxy coffee consumption. Summary-level data for the relations between the 12 genetic variants and cardiovascular diseases were taken from the UK Biobank with up to 35,979 cases and the FinnGen consortium with up to 17,325 cases. Genetic predisposition to higher coffee consumption was not associated with any of the 15 studied cardiovascular outcomes in univariable MR analysis. The odds ratio per 50% increase in genetically predicted coffee consumption ranged from 0.97 (95% confidence interval (CI), 0.63, 1.50) for intracerebral hemorrhage to 1.26 (95% CI, 1.00, 1.58) for deep vein thrombosis in the UK Biobank and from 0.86 (95% CI, 0.50, 1.49) for subarachnoid hemorrhage to 1.34 (95% CI, 0.81, 2.22) for intracerebral hemorrhage in FinnGen. The null findings remained in multivariable Mendelian randomization analyses adjusted for genetically predicted body mass index and smoking initiation, except for a suggestive positive association for intracerebral hemorrhage (odds ratio 1.91; 95% CI, 1.03, 3.54) in FinnGen. This Mendelian randomization study showed limited evidence that coffee consumption affects the risk of developing cardiovascular disease, suggesting that previous observational studies may have been confounded.
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spelling pubmed-83084562021-07-25 Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study Yuan, Shuai Carter, Paul Mason, Amy M. Burgess, Stephen Larsson, Susanna C. Nutrients Article Coffee consumption has been linked to a lower risk of cardiovascular disease in observational studies, but whether the associations are causal is not known. We conducted a Mendelian randomization investigation to assess the potential causal role of coffee consumption in cardiovascular disease. Twelve independent genetic variants were used to proxy coffee consumption. Summary-level data for the relations between the 12 genetic variants and cardiovascular diseases were taken from the UK Biobank with up to 35,979 cases and the FinnGen consortium with up to 17,325 cases. Genetic predisposition to higher coffee consumption was not associated with any of the 15 studied cardiovascular outcomes in univariable MR analysis. The odds ratio per 50% increase in genetically predicted coffee consumption ranged from 0.97 (95% confidence interval (CI), 0.63, 1.50) for intracerebral hemorrhage to 1.26 (95% CI, 1.00, 1.58) for deep vein thrombosis in the UK Biobank and from 0.86 (95% CI, 0.50, 1.49) for subarachnoid hemorrhage to 1.34 (95% CI, 0.81, 2.22) for intracerebral hemorrhage in FinnGen. The null findings remained in multivariable Mendelian randomization analyses adjusted for genetically predicted body mass index and smoking initiation, except for a suggestive positive association for intracerebral hemorrhage (odds ratio 1.91; 95% CI, 1.03, 3.54) in FinnGen. This Mendelian randomization study showed limited evidence that coffee consumption affects the risk of developing cardiovascular disease, suggesting that previous observational studies may have been confounded. MDPI 2021-06-28 /pmc/articles/PMC8308456/ /pubmed/34203356 http://dx.doi.org/10.3390/nu13072218 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Shuai
Carter, Paul
Mason, Amy M.
Burgess, Stephen
Larsson, Susanna C.
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title_full Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title_fullStr Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title_full_unstemmed Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title_short Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
title_sort coffee consumption and cardiovascular diseases: a mendelian randomization study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308456/
https://www.ncbi.nlm.nih.gov/pubmed/34203356
http://dx.doi.org/10.3390/nu13072218
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