Cargando…

Probiotics in Pediatrics. A Review and Practical Guide

The potential benefit of the administration of probiotics in children has been studied in many settings globally. Probiotics products contain viable micro-organisms that confer a health benefit on the host. Beneficial effects of selected probiotic strains for the management or prevention of selected...

Descripción completa

Detalles Bibliográficos
Autores principales: Depoorter, Leontien, Vandenplas, Yvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308463/
https://www.ncbi.nlm.nih.gov/pubmed/34202742
http://dx.doi.org/10.3390/nu13072176
_version_ 1783728287171739648
author Depoorter, Leontien
Vandenplas, Yvan
author_facet Depoorter, Leontien
Vandenplas, Yvan
author_sort Depoorter, Leontien
collection PubMed
description The potential benefit of the administration of probiotics in children has been studied in many settings globally. Probiotics products contain viable micro-organisms that confer a health benefit on the host. Beneficial effects of selected probiotic strains for the management or prevention of selected pediatric conditions have been demonstrated. The purpose of this paper is to provide an overview of current available evidence on the efficacy of specific probiotics in selected conditions to guide pediatricians in decision-making on the therapeutic or prophylactic use of probiotic strains in children. Evidence to support the use of certain probiotics in selected pediatric conditions is often available. In addition, the administration of probiotics is associated with a low risk of adverse events and is generally well tolerated. The best documented efficacy of certain probiotics is for treatment of infectious gastroenteritis, and prevention of antibiotic-associated, Clostridioides difficile-associated and nosocomial diarrhea. Unfortunately, due to study heterogeneity and in some cases high risk of bias in published studies, a broad consensus is lacking for specific probiotic strains, doses and treatment regimens for some pediatric indications. The current available evidence thus limits the systematic administration of probiotics. The most recent meta-analyses and reviews highlight the need for more well-designed, properly powered, strain-specific and dedicated-dose response studies.
format Online
Article
Text
id pubmed-8308463
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83084632021-07-25 Probiotics in Pediatrics. A Review and Practical Guide Depoorter, Leontien Vandenplas, Yvan Nutrients Review The potential benefit of the administration of probiotics in children has been studied in many settings globally. Probiotics products contain viable micro-organisms that confer a health benefit on the host. Beneficial effects of selected probiotic strains for the management or prevention of selected pediatric conditions have been demonstrated. The purpose of this paper is to provide an overview of current available evidence on the efficacy of specific probiotics in selected conditions to guide pediatricians in decision-making on the therapeutic or prophylactic use of probiotic strains in children. Evidence to support the use of certain probiotics in selected pediatric conditions is often available. In addition, the administration of probiotics is associated with a low risk of adverse events and is generally well tolerated. The best documented efficacy of certain probiotics is for treatment of infectious gastroenteritis, and prevention of antibiotic-associated, Clostridioides difficile-associated and nosocomial diarrhea. Unfortunately, due to study heterogeneity and in some cases high risk of bias in published studies, a broad consensus is lacking for specific probiotic strains, doses and treatment regimens for some pediatric indications. The current available evidence thus limits the systematic administration of probiotics. The most recent meta-analyses and reviews highlight the need for more well-designed, properly powered, strain-specific and dedicated-dose response studies. MDPI 2021-06-24 /pmc/articles/PMC8308463/ /pubmed/34202742 http://dx.doi.org/10.3390/nu13072176 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Depoorter, Leontien
Vandenplas, Yvan
Probiotics in Pediatrics. A Review and Practical Guide
title Probiotics in Pediatrics. A Review and Practical Guide
title_full Probiotics in Pediatrics. A Review and Practical Guide
title_fullStr Probiotics in Pediatrics. A Review and Practical Guide
title_full_unstemmed Probiotics in Pediatrics. A Review and Practical Guide
title_short Probiotics in Pediatrics. A Review and Practical Guide
title_sort probiotics in pediatrics. a review and practical guide
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308463/
https://www.ncbi.nlm.nih.gov/pubmed/34202742
http://dx.doi.org/10.3390/nu13072176
work_keys_str_mv AT depoorterleontien probioticsinpediatricsareviewandpracticalguide
AT vandenplasyvan probioticsinpediatricsareviewandpracticalguide