Cargando…
Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses
The aim of this study was to examine the association between coffee and prostate cancer. Firstly, we conducted an observational study using data from National Health and Nutrition Examination Survey (NHANES) 1999–2010. Coffee intake was derived from 24 h dietary recalls. Weighted multivariable-adjus...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308488/ https://www.ncbi.nlm.nih.gov/pubmed/34371827 http://dx.doi.org/10.3390/nu13072317 |
_version_ | 1783728293134991360 |
---|---|
author | Wang, Menghua Jian, Zhongyu Yuan, Chi Jin, Xi Li, Hong Wang, Kunjie |
author_facet | Wang, Menghua Jian, Zhongyu Yuan, Chi Jin, Xi Li, Hong Wang, Kunjie |
author_sort | Wang, Menghua |
collection | PubMed |
description | The aim of this study was to examine the association between coffee and prostate cancer. Firstly, we conducted an observational study using data from National Health and Nutrition Examination Survey (NHANES) 1999–2010. Coffee intake was derived from 24 h dietary recalls. Weighted multivariable-adjusted logistic regression was applied to evaluate the association. Then, we performed Mendelian randomization (MR) to explore the possible causal effect of coffee on prostate cancer risk. Primary and secondary genetic instruments were obtained from genome-wide association studies among 375,833 and 91,462 individuals separately. Prostate cancer summary statistics were extracted from Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome (PRACTICAL) (79,194 cases and 61,112 controls) and FinnGen project (4754 cases and 63,465 controls). Inverse variance weighted (IVW) was the primary analytical method. Through selection, we enrolled 8336 individuals (weighted number = 58,796,070) for our observational study in NHANES. Results suggested that there was no association between coffee and prostate cancer. MR analyses with primary genetic instruments also did not support a causal association between coffee intake and prostate cancer risk, whether using summary data from PRACTICAL (IVW: OR 1.001, 95% CI 0.997–1.005) or FinnGen (IVW: OR 1.005, 95% CI 0.998–1.012). Similar results were observed when using secondary genetic instruments. Therefore, our study did not support a causal association between coffee intake and prostate cancer risk. Further studies with a larger sample size are needed to examine if an association exists by different coffee bean types, roasting procedures, and brewing methods. |
format | Online Article Text |
id | pubmed-8308488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83084882021-07-25 Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses Wang, Menghua Jian, Zhongyu Yuan, Chi Jin, Xi Li, Hong Wang, Kunjie Nutrients Article The aim of this study was to examine the association between coffee and prostate cancer. Firstly, we conducted an observational study using data from National Health and Nutrition Examination Survey (NHANES) 1999–2010. Coffee intake was derived from 24 h dietary recalls. Weighted multivariable-adjusted logistic regression was applied to evaluate the association. Then, we performed Mendelian randomization (MR) to explore the possible causal effect of coffee on prostate cancer risk. Primary and secondary genetic instruments were obtained from genome-wide association studies among 375,833 and 91,462 individuals separately. Prostate cancer summary statistics were extracted from Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome (PRACTICAL) (79,194 cases and 61,112 controls) and FinnGen project (4754 cases and 63,465 controls). Inverse variance weighted (IVW) was the primary analytical method. Through selection, we enrolled 8336 individuals (weighted number = 58,796,070) for our observational study in NHANES. Results suggested that there was no association between coffee and prostate cancer. MR analyses with primary genetic instruments also did not support a causal association between coffee intake and prostate cancer risk, whether using summary data from PRACTICAL (IVW: OR 1.001, 95% CI 0.997–1.005) or FinnGen (IVW: OR 1.005, 95% CI 0.998–1.012). Similar results were observed when using secondary genetic instruments. Therefore, our study did not support a causal association between coffee intake and prostate cancer risk. Further studies with a larger sample size are needed to examine if an association exists by different coffee bean types, roasting procedures, and brewing methods. MDPI 2021-07-05 /pmc/articles/PMC8308488/ /pubmed/34371827 http://dx.doi.org/10.3390/nu13072317 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Menghua Jian, Zhongyu Yuan, Chi Jin, Xi Li, Hong Wang, Kunjie Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title | Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title_full | Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title_fullStr | Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title_full_unstemmed | Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title_short | Coffee Consumption and Prostate Cancer Risk: Results from National Health and Nutrition Examination Survey 1999–2010 and Mendelian Randomization Analyses |
title_sort | coffee consumption and prostate cancer risk: results from national health and nutrition examination survey 1999–2010 and mendelian randomization analyses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308488/ https://www.ncbi.nlm.nih.gov/pubmed/34371827 http://dx.doi.org/10.3390/nu13072317 |
work_keys_str_mv | AT wangmenghua coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses AT jianzhongyu coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses AT yuanchi coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses AT jinxi coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses AT lihong coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses AT wangkunjie coffeeconsumptionandprostatecancerriskresultsfromnationalhealthandnutritionexaminationsurvey19992010andmendelianrandomizationanalyses |