Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein

The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal repli...

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Autores principales: Jose, Leny, Gilson, Timra, Androphy, Elliot J., DeSmet, Marsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308518/
https://www.ncbi.nlm.nih.gov/pubmed/34201556
http://dx.doi.org/10.3390/pathogens10070793
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author Jose, Leny
Gilson, Timra
Androphy, Elliot J.
DeSmet, Marsha
author_facet Jose, Leny
Gilson, Timra
Androphy, Elliot J.
DeSmet, Marsha
author_sort Jose, Leny
collection PubMed
description The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal replication throughout the viral lifecycle. The E2 protein is regulated by phosphorylation, acetylation, sumoylation, and ubiquitination. In this mini-review, we summarize the recent advancements made to identify post translational modifications within E2 and their ability to control viral replication.
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spelling pubmed-83085182021-07-25 Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein Jose, Leny Gilson, Timra Androphy, Elliot J. DeSmet, Marsha Pathogens Review The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal replication throughout the viral lifecycle. The E2 protein is regulated by phosphorylation, acetylation, sumoylation, and ubiquitination. In this mini-review, we summarize the recent advancements made to identify post translational modifications within E2 and their ability to control viral replication. MDPI 2021-06-23 /pmc/articles/PMC8308518/ /pubmed/34201556 http://dx.doi.org/10.3390/pathogens10070793 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jose, Leny
Gilson, Timra
Androphy, Elliot J.
DeSmet, Marsha
Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_full Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_fullStr Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_full_unstemmed Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_short Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein
title_sort regulation of the human papillomavirus lifecyle through post-translational modifications of the viral e2 protein
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308518/
https://www.ncbi.nlm.nih.gov/pubmed/34201556
http://dx.doi.org/10.3390/pathogens10070793
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