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Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial

Cellulite describes unsightly skin overlying subcutaneous fat around thighs and buttocks of post-pubescent females. A herbal ‘emgel’ containing volatile oils and extracts of A traditional Thai herbal compress was tested in a double-blind, placebo-controlled trial with 18 women aged 20–50 year with s...

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Autores principales: Ngamdokmai, Ngamrayu, Waranuch, Neti, Chootip, Krongkarn, Jampachaisri, Katechan, Scholfield, C. Norman, Ingkaninan, Kornkanok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308550/
https://www.ncbi.nlm.nih.gov/pubmed/34358109
http://dx.doi.org/10.3390/ph14070683
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author Ngamdokmai, Ngamrayu
Waranuch, Neti
Chootip, Krongkarn
Jampachaisri, Katechan
Scholfield, C. Norman
Ingkaninan, Kornkanok
author_facet Ngamdokmai, Ngamrayu
Waranuch, Neti
Chootip, Krongkarn
Jampachaisri, Katechan
Scholfield, C. Norman
Ingkaninan, Kornkanok
author_sort Ngamdokmai, Ngamrayu
collection PubMed
description Cellulite describes unsightly skin overlying subcutaneous fat around thighs and buttocks of post-pubescent females. A herbal ‘emgel’ containing volatile oils and extracts of A traditional Thai herbal compress was tested in a double-blind, placebo-controlled trial with 18 women aged 20–50 year with severe cellulite. Appearance of cellulite (primary outcome), thigh circumferences, skin firmness, and cutaneous blood flow (secondary outcomes) were assessed at baseline, 2, 4, 8 and 12 weeks with a 2-week follow-up. Herbal emgel applied onto the thigh skin twice daily reduced cellulite severity scores in every time point. The score was reduced from 13.4 ± 0.3 (baseline) to 12.1 ± 0.3 (week 2) and 9.9 ± 0.6 (week 12). All secondary outcomes improved with both placebo and herbal emgels suggesting that ingredients in the base-formulation might be responsible. Querying of participants, analysis of their diaries, and physical monthly inspections found no adverse events. The herbal emgel safely improved the appearance of cellulite, while the base emgel may play a role for other endpoints. Further studies on the active constituents and their mechanism of action are needed to further explore these factors.
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spelling pubmed-83085502021-07-25 Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial Ngamdokmai, Ngamrayu Waranuch, Neti Chootip, Krongkarn Jampachaisri, Katechan Scholfield, C. Norman Ingkaninan, Kornkanok Pharmaceuticals (Basel) Article Cellulite describes unsightly skin overlying subcutaneous fat around thighs and buttocks of post-pubescent females. A herbal ‘emgel’ containing volatile oils and extracts of A traditional Thai herbal compress was tested in a double-blind, placebo-controlled trial with 18 women aged 20–50 year with severe cellulite. Appearance of cellulite (primary outcome), thigh circumferences, skin firmness, and cutaneous blood flow (secondary outcomes) were assessed at baseline, 2, 4, 8 and 12 weeks with a 2-week follow-up. Herbal emgel applied onto the thigh skin twice daily reduced cellulite severity scores in every time point. The score was reduced from 13.4 ± 0.3 (baseline) to 12.1 ± 0.3 (week 2) and 9.9 ± 0.6 (week 12). All secondary outcomes improved with both placebo and herbal emgels suggesting that ingredients in the base-formulation might be responsible. Querying of participants, analysis of their diaries, and physical monthly inspections found no adverse events. The herbal emgel safely improved the appearance of cellulite, while the base emgel may play a role for other endpoints. Further studies on the active constituents and their mechanism of action are needed to further explore these factors. MDPI 2021-07-16 /pmc/articles/PMC8308550/ /pubmed/34358109 http://dx.doi.org/10.3390/ph14070683 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ngamdokmai, Ngamrayu
Waranuch, Neti
Chootip, Krongkarn
Jampachaisri, Katechan
Scholfield, C. Norman
Ingkaninan, Kornkanok
Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title_full Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title_fullStr Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title_full_unstemmed Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title_short Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
title_sort efficacy of an anti-cellulite herbal emgel: a randomized clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308550/
https://www.ncbi.nlm.nih.gov/pubmed/34358109
http://dx.doi.org/10.3390/ph14070683
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