Pyruvate Kinase, Inflammation and Periodontal Disease

Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the in...

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Detalles Bibliográficos
Autor principal: Grant, Melissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308603/
https://www.ncbi.nlm.nih.gov/pubmed/34206267
http://dx.doi.org/10.3390/pathogens10070784
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author Grant, Melissa M.
author_facet Grant, Melissa M.
author_sort Grant, Melissa M.
collection PubMed
description Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.
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spelling pubmed-83086032021-07-25 Pyruvate Kinase, Inflammation and Periodontal Disease Grant, Melissa M. Pathogens Review Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease. MDPI 2021-06-22 /pmc/articles/PMC8308603/ /pubmed/34206267 http://dx.doi.org/10.3390/pathogens10070784 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grant, Melissa M.
Pyruvate Kinase, Inflammation and Periodontal Disease
title Pyruvate Kinase, Inflammation and Periodontal Disease
title_full Pyruvate Kinase, Inflammation and Periodontal Disease
title_fullStr Pyruvate Kinase, Inflammation and Periodontal Disease
title_full_unstemmed Pyruvate Kinase, Inflammation and Periodontal Disease
title_short Pyruvate Kinase, Inflammation and Periodontal Disease
title_sort pyruvate kinase, inflammation and periodontal disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308603/
https://www.ncbi.nlm.nih.gov/pubmed/34206267
http://dx.doi.org/10.3390/pathogens10070784
work_keys_str_mv AT grantmelissam pyruvatekinaseinflammationandperiodontaldisease

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