Deletion Mutants of Francisella Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal Francisella LVS Challenge in a Murine Model of Respiratory Tularemia

Francisella tularensis (Ft) is a Gram-negative, facultative intracellular bacterium that is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. A subfamily of 9 Francisella phagosomal transporter (fpt) genes belonging to the Major Facilitator Superfamily of transp...

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Detalles Bibliográficos
Autores principales: Hobbs, Brandi E., Matson, Courtney A., Theofilou, Vasileios I., Webb, Tonya J., Younis, Rania H., Barry, Eileen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308642/
https://www.ncbi.nlm.nih.gov/pubmed/34202420
http://dx.doi.org/10.3390/pathogens10070799

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