Rickettsia parkeri with a Genetically Disrupted Phage Integrase Gene Exhibits Attenuated Virulence and Induces Protective Immunity against Fatal Rickettsioses in Mice

Although rickettsiae can cause life-threatening infections in humans worldwide, no licensed vaccine is currently available. To evaluate the suitability of live-attenuated vaccine candidates against rickettsioses, we generated a Rickettsia parkeri mutant RPATATE_0245::pLoxHimar (named 3A2) by inserti...

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Detalles Bibliográficos
Autores principales: Arroyave, Esteban, Hyseni, Ilirjana, Burkhardt, Nicole, Kuo, Yong-Fang, Wang, Tian, Munderloh, Ulrike, Fang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308654/
https://www.ncbi.nlm.nih.gov/pubmed/34208806
http://dx.doi.org/10.3390/pathogens10070819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308654/
https://www.ncbi.nlm.nih.gov/pubmed/34208806
http://dx.doi.org/10.3390/pathogens10070819

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