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The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity

Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their prot...

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Autores principales: Czogała, Wojciech, Strojny, Wojciech, Tomasik, Przemysław, Multanowski, Mirosław Bik, Wójcik, Małgorzata, Miklusiak, Klaudia, Krzysztofik, Emil, Wróbel, Albert, Miklusiak, Karol, Skoczeń, Szymon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308664/
https://www.ncbi.nlm.nih.gov/pubmed/34371941
http://dx.doi.org/10.3390/nu13072432
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author Czogała, Wojciech
Strojny, Wojciech
Tomasik, Przemysław
Multanowski, Mirosław Bik
Wójcik, Małgorzata
Miklusiak, Klaudia
Krzysztofik, Emil
Wróbel, Albert
Miklusiak, Karol
Skoczeń, Szymon
author_facet Czogała, Wojciech
Strojny, Wojciech
Tomasik, Przemysław
Multanowski, Mirosław Bik
Wójcik, Małgorzata
Miklusiak, Klaudia
Krzysztofik, Emil
Wróbel, Albert
Miklusiak, Karol
Skoczeń, Szymon
author_sort Czogała, Wojciech
collection PubMed
description Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation.
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spelling pubmed-83086642021-07-25 The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity Czogała, Wojciech Strojny, Wojciech Tomasik, Przemysław Multanowski, Mirosław Bik Wójcik, Małgorzata Miklusiak, Klaudia Krzysztofik, Emil Wróbel, Albert Miklusiak, Karol Skoczeń, Szymon Nutrients Article Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation. MDPI 2021-07-15 /pmc/articles/PMC8308664/ /pubmed/34371941 http://dx.doi.org/10.3390/nu13072432 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Czogała, Wojciech
Strojny, Wojciech
Tomasik, Przemysław
Multanowski, Mirosław Bik
Wójcik, Małgorzata
Miklusiak, Klaudia
Krzysztofik, Emil
Wróbel, Albert
Miklusiak, Karol
Skoczeń, Szymon
The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title_full The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title_fullStr The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title_full_unstemmed The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title_short The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
title_sort insight into insulin-like growth factors and insulin-like growth-factor-binding proteins and metabolic profile in pediatric obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308664/
https://www.ncbi.nlm.nih.gov/pubmed/34371941
http://dx.doi.org/10.3390/nu13072432
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