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The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their prot...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308664/ https://www.ncbi.nlm.nih.gov/pubmed/34371941 http://dx.doi.org/10.3390/nu13072432 |
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author | Czogała, Wojciech Strojny, Wojciech Tomasik, Przemysław Multanowski, Mirosław Bik Wójcik, Małgorzata Miklusiak, Klaudia Krzysztofik, Emil Wróbel, Albert Miklusiak, Karol Skoczeń, Szymon |
author_facet | Czogała, Wojciech Strojny, Wojciech Tomasik, Przemysław Multanowski, Mirosław Bik Wójcik, Małgorzata Miklusiak, Klaudia Krzysztofik, Emil Wróbel, Albert Miklusiak, Karol Skoczeń, Szymon |
author_sort | Czogała, Wojciech |
collection | PubMed |
description | Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation. |
format | Online Article Text |
id | pubmed-8308664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83086642021-07-25 The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity Czogała, Wojciech Strojny, Wojciech Tomasik, Przemysław Multanowski, Mirosław Bik Wójcik, Małgorzata Miklusiak, Klaudia Krzysztofik, Emil Wróbel, Albert Miklusiak, Karol Skoczeń, Szymon Nutrients Article Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation. MDPI 2021-07-15 /pmc/articles/PMC8308664/ /pubmed/34371941 http://dx.doi.org/10.3390/nu13072432 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Czogała, Wojciech Strojny, Wojciech Tomasik, Przemysław Multanowski, Mirosław Bik Wójcik, Małgorzata Miklusiak, Klaudia Krzysztofik, Emil Wróbel, Albert Miklusiak, Karol Skoczeń, Szymon The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title | The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title_full | The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title_fullStr | The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title_full_unstemmed | The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title_short | The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity |
title_sort | insight into insulin-like growth factors and insulin-like growth-factor-binding proteins and metabolic profile in pediatric obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308664/ https://www.ncbi.nlm.nih.gov/pubmed/34371941 http://dx.doi.org/10.3390/nu13072432 |
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