Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis

Candida parapsilosis infections are increasingly reported in preterm neonates, but the optimal treatment remains uncertain. We report the clinical history of an extremely preterm neonate, who developed a devastating skin necrosis due to terlipressin administration, with subsequent superinfection by...

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Autores principales: De Rose, Domenico Umberto, Piersigilli, Fiammetta, Goffredo, Bianca Maria, Danhaive, Olivier, Dotta, Andrea, Auriti, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308678/
https://www.ncbi.nlm.nih.gov/pubmed/34358040
http://dx.doi.org/10.3390/pathogens10070890
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author De Rose, Domenico Umberto
Piersigilli, Fiammetta
Goffredo, Bianca Maria
Danhaive, Olivier
Dotta, Andrea
Auriti, Cinzia
author_facet De Rose, Domenico Umberto
Piersigilli, Fiammetta
Goffredo, Bianca Maria
Danhaive, Olivier
Dotta, Andrea
Auriti, Cinzia
author_sort De Rose, Domenico Umberto
collection PubMed
description Candida parapsilosis infections are increasingly reported in preterm neonates, but the optimal treatment remains uncertain. We report the clinical history of an extremely preterm neonate, who developed a devastating skin necrosis due to terlipressin administration, with subsequent superinfection by Candida parapsilosis. The infant underwent multiple curettages and skin grafts to resolve skin lesions and was treated with systemic micafungin administration at a high dose (8 mg/kg/day), with resolution of the fungal infection.
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spelling pubmed-83086782021-07-25 Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis De Rose, Domenico Umberto Piersigilli, Fiammetta Goffredo, Bianca Maria Danhaive, Olivier Dotta, Andrea Auriti, Cinzia Pathogens Brief Report Candida parapsilosis infections are increasingly reported in preterm neonates, but the optimal treatment remains uncertain. We report the clinical history of an extremely preterm neonate, who developed a devastating skin necrosis due to terlipressin administration, with subsequent superinfection by Candida parapsilosis. The infant underwent multiple curettages and skin grafts to resolve skin lesions and was treated with systemic micafungin administration at a high dose (8 mg/kg/day), with resolution of the fungal infection. MDPI 2021-07-13 /pmc/articles/PMC8308678/ /pubmed/34358040 http://dx.doi.org/10.3390/pathogens10070890 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
De Rose, Domenico Umberto
Piersigilli, Fiammetta
Goffredo, Bianca Maria
Danhaive, Olivier
Dotta, Andrea
Auriti, Cinzia
Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title_full Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title_fullStr Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title_full_unstemmed Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title_short Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis
title_sort treatment with micafungin in a preterm neonate with an invasive candida parapsilosis infection after a severe terlipressin-induced skin necrosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308678/
https://www.ncbi.nlm.nih.gov/pubmed/34358040
http://dx.doi.org/10.3390/pathogens10070890
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