Cargando…
A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus
The aim of this study was to compare the virulence of porcine circovirus type 2 (PCV2) genotypes in dually inoculated pigs with both three genotypes (a, b, and d) of PCV2 and porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) versus pigs singularly inoculated with the same three PCV2 ge...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308741/ https://www.ncbi.nlm.nih.gov/pubmed/34358041 http://dx.doi.org/10.3390/pathogens10070891 |
_version_ | 1783728353819230208 |
---|---|
author | Suh, Jeongmin Oh, Taehwan Park, Keehwan Yang, Siyeon Cho, Hyejean Chae, Chanhee |
author_facet | Suh, Jeongmin Oh, Taehwan Park, Keehwan Yang, Siyeon Cho, Hyejean Chae, Chanhee |
author_sort | Suh, Jeongmin |
collection | PubMed |
description | The aim of this study was to compare the virulence of porcine circovirus type 2 (PCV2) genotypes in dually inoculated pigs with both three genotypes (a, b, and d) of PCV2 and porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) versus pigs singularly inoculated with the same three PCV2 genotypes (a, b, and d). Differences in this comparison were found in PCV2 viremia levels, lung and lymphoid lesion severity, and the amount of PCV2 antigen within the lymphoid lesions. Regardless of PCV2 genotypes, pigs that were dually inoculated with PCV2/PRRSV had significantly higher clinical scores, less average daily weight gain, higher levels of PCV2 viremia, and more severe lug and lymphoid lesions compared to pigs singularly inoculated with PCV2. Among the dually infected pig groups, pigs infected with PCV2d/PRRSV-2 had significantly higher levels of PCV2 viremia, more severe lung and lymphoid lesions, and more PCV2-positive cells within lymphoid lesions compared to pigs dually inoculated with PCV2a/PRRSV-2 and PCV2b/PRRSV-2. The results of this study demonstrated significant differences in the virulence among dual inoculation of PCV2a/PRRSV-2, PCV2b/PRRSV-2, and PCV2d/PRRSV-2. A significant difference in the virulence among PCV2a, PCV2b, and PCV2d single-inoculated pig groups was not found with respect to the levels of PCV2 viremia and production of PCV2-associated lymphoid lesions. |
format | Online Article Text |
id | pubmed-8308741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83087412021-07-25 A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus Suh, Jeongmin Oh, Taehwan Park, Keehwan Yang, Siyeon Cho, Hyejean Chae, Chanhee Pathogens Article The aim of this study was to compare the virulence of porcine circovirus type 2 (PCV2) genotypes in dually inoculated pigs with both three genotypes (a, b, and d) of PCV2 and porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) versus pigs singularly inoculated with the same three PCV2 genotypes (a, b, and d). Differences in this comparison were found in PCV2 viremia levels, lung and lymphoid lesion severity, and the amount of PCV2 antigen within the lymphoid lesions. Regardless of PCV2 genotypes, pigs that were dually inoculated with PCV2/PRRSV had significantly higher clinical scores, less average daily weight gain, higher levels of PCV2 viremia, and more severe lug and lymphoid lesions compared to pigs singularly inoculated with PCV2. Among the dually infected pig groups, pigs infected with PCV2d/PRRSV-2 had significantly higher levels of PCV2 viremia, more severe lung and lymphoid lesions, and more PCV2-positive cells within lymphoid lesions compared to pigs dually inoculated with PCV2a/PRRSV-2 and PCV2b/PRRSV-2. The results of this study demonstrated significant differences in the virulence among dual inoculation of PCV2a/PRRSV-2, PCV2b/PRRSV-2, and PCV2d/PRRSV-2. A significant difference in the virulence among PCV2a, PCV2b, and PCV2d single-inoculated pig groups was not found with respect to the levels of PCV2 viremia and production of PCV2-associated lymphoid lesions. MDPI 2021-07-14 /pmc/articles/PMC8308741/ /pubmed/34358041 http://dx.doi.org/10.3390/pathogens10070891 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suh, Jeongmin Oh, Taehwan Park, Keehwan Yang, Siyeon Cho, Hyejean Chae, Chanhee A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title | A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title_full | A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title_fullStr | A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title_full_unstemmed | A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title_short | A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus |
title_sort | comparison of virulence of three porcine circovirus type 2 (pcv2) genotypes (a, b, and d) in pigs singularly inoculated with pcv2 and dually inoculated with pcv2 and porcine reproductive and respiratory syndrome virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308741/ https://www.ncbi.nlm.nih.gov/pubmed/34358041 http://dx.doi.org/10.3390/pathogens10070891 |
work_keys_str_mv | AT suhjeongmin acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT ohtaehwan acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT parkkeehwan acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT yangsiyeon acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT chohyejean acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT chaechanhee acomparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT suhjeongmin comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT ohtaehwan comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT parkkeehwan comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT yangsiyeon comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT chohyejean comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus AT chaechanhee comparisonofvirulenceofthreeporcinecircovirustype2pcv2genotypesabanddinpigssingularlyinoculatedwithpcv2andduallyinoculatedwithpcv2andporcinereproductiveandrespiratorysyndromevirus |