Cargando…

Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor efficacy have not been reported. Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Minsung, Kim, Chijung, Leem, Jiyeon, Kim, Ye-hyun, Kwon, Young-ju, Yoon, Yi Na, Chae, Chong Hak, Ahn, Jiyeon, Jung, Kwan-Young, Oh, Jeong Su, Kim, Jae-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308786/ https://www.ncbi.nlm.nih.gov/pubmed/34358073 http://dx.doi.org/10.3390/ph14070647

Ejemplares similares

MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer
por: Kim, Ah-Young, et al.
Publicado: (2020)

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting
por: Conway, James Ronald William, et al.
Publicado: (2020)

The Oncogenic Functions of MASTL Kinase
por: Marzec, Kamila, et al.
Publicado: (2018)

Mastl/PP2A regulate Cdk1 in ooycte maturation
por: Adhikari, Deepak, et al.
Publicado: (2015)

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells
por: Yoon, Yi Na, et al.
Publicado: (2018)

MASTL: A novel therapeutic target for Cancer Malignancy
por: Fatima, Iram, et al.
Publicado: (2020)

SILAC kinase screen identifies potential MASTL substrates
por: Marzec, Kamila A., et al.
Publicado: (2022)

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells
por: Rogers, Samuel, et al.
Publicado: (2016)

Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer
por: Álvarez-Fernández, Mónica, et al.
Publicado: (2017)

MASTL overexpression promotes chromosome instability and metastasis in breast cancer
por: Rogers, Samuel, et al.
Publicado: (2018)

Mastl kinase, a promising therapeutic target, promotes cancer recurrence
por: Wang, Ling, et al.
Publicado: (2014)

MASTL promotes cell contractility and motility through kinase-independent signaling
por: Taskinen, Maria Emilia, et al.
Publicado: (2020)

The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma
por: Gouttia, Odjo G., et al.
Publicado: (2022)

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling
por: Uppada, Srijayaprakash Babu, et al.
Publicado: (2018)

Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression
por: Cao, Liye, et al.
Publicado: (2019)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
por: Närvä, Elisa, et al.
Publicado: (2022)

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II
por: Adhikari, Deepak, et al.
Publicado: (2014)

MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice
por: Risal, Sanjiv, et al.
Publicado: (2017)

Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer
por: Sun, Xian-Jun, et al.
Publicado: (2017)

Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation
por: Polisety, Aneesha, et al.
Publicado: (2022)

MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
por: Wong, Po Yee, et al.
Publicado: (2016)

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C
por: Voets, Erik, et al.
Publicado: (2015)

MKI UFOs at Injection
por: Baer, T, et al.
Publicado: (2011)

Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI
por: Zha, Manwu, et al.
Publicado: (2012)

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A–MDC1–TOPBP1 complex from spindle pole to chromosomes
por: Leem, Jiyeon, et al.
Publicado: (2023)

HL-LHC kicker magnet (MKI)
por: Brice, Maximilien
Publicado: (2018)

Installation of the first MKI for the HL-LHC
por: Brice, Maximilien
Publicado: (2023)

MKI’s alumina tube discrimination and optimisation
por: Maurin, Theo
Publicado: (2021)

Increased WIP1 Expression With Aging Suppresses the Capacity of Oocytes to Respond to and Repair DNA Damage
por: Leem, Jiyeon, et al.
Publicado: (2021)

MKI performance during 2016 and plans for EYETS
por: Barnes, M J, et al.
Publicado: (2017)

Selective utilization of non‐homologous end‐joining and homologous recombination for DNA repair during meiotic maturation in mouse oocytes
por: Lee, Crystal, et al.
Publicado: (2022)

PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer
por: Kang, Minsung, et al.
Publicado: (2022)

Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors
por: Kim, Hyo Jeong, et al.
Publicado: (2020)

MKI67 as a potential diagnostic biomarker in pulmonary hypertension
por: Zhou, Huiling, et al.
Publicado: (2022)

Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
por: Neal, Scott J, et al.
Publicado: (2015)

A Novel Aminothiazole KY-05009 with Potential to Inhibit Traf2- and Nck-Interacting Kinase (TNIK) Attenuates TGF-β1-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Adenocarcinoma A549 Cells
por: Kim, Jiyeon, et al.
Publicado: (2014)

Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
por: Neal, Scott J, et al.
Publicado: (2015)

Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor
por: Ryu, Hwani, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nk4tiuc3hrc3jk5b1m2ica2u3d