Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and t...

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Autores principales: Xu, Jinghang, Zhan, Qiao, Fan, Yanan, Lo, Emily Kwun Kwan, Zhang, Fangfei, Yu, Yanyan, El-Nezami, Hani, Zeng, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308793/
https://www.ncbi.nlm.nih.gov/pubmed/34206200
http://dx.doi.org/10.3390/pathogens10070782
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author Xu, Jinghang
Zhan, Qiao
Fan, Yanan
Lo, Emily Kwun Kwan
Zhang, Fangfei
Yu, Yanyan
El-Nezami, Hani
Zeng, Zheng
author_facet Xu, Jinghang
Zhan, Qiao
Fan, Yanan
Lo, Emily Kwun Kwan
Zhang, Fangfei
Yu, Yanyan
El-Nezami, Hani
Zeng, Zheng
author_sort Xu, Jinghang
collection PubMed
description Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development.
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spelling pubmed-83087932021-07-25 Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management Xu, Jinghang Zhan, Qiao Fan, Yanan Lo, Emily Kwun Kwan Zhang, Fangfei Yu, Yanyan El-Nezami, Hani Zeng, Zheng Pathogens Review Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development. MDPI 2021-06-22 /pmc/articles/PMC8308793/ /pubmed/34206200 http://dx.doi.org/10.3390/pathogens10070782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Jinghang
Zhan, Qiao
Fan, Yanan
Lo, Emily Kwun Kwan
Zhang, Fangfei
Yu, Yanyan
El-Nezami, Hani
Zeng, Zheng
Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_full Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_fullStr Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_full_unstemmed Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_short Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_sort clinical aspects of gut microbiota in hepatocellular carcinoma management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308793/
https://www.ncbi.nlm.nih.gov/pubmed/34206200
http://dx.doi.org/10.3390/pathogens10070782
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