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Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol
Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308883/ https://www.ncbi.nlm.nih.gov/pubmed/34358061 http://dx.doi.org/10.3390/pathogens10070911 |
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author | Pouquet, Marie Decarreaux, Dorine Prévot-Monsacré, Pol Hervé, Corentin Werner, Andréas Grosgogeat, Brigitte Blanché, Hélène Rabiega, Pascaline Laupie, Julien Kochert, Fabienne Abraham, Nathalie Sebaoun, Jean-Marc de Lamballerie, Xavier Charrel, Remi Souty, Cecile Camara, Ibrahima Pergeline, Jeanne Noël, Harold Guerrisi, Caroline van der Werf, Sylvie Carrat, Fabrice Hanslik, Thomas Blanchon, Thierry Falchi, Alessandra |
author_facet | Pouquet, Marie Decarreaux, Dorine Prévot-Monsacré, Pol Hervé, Corentin Werner, Andréas Grosgogeat, Brigitte Blanché, Hélène Rabiega, Pascaline Laupie, Julien Kochert, Fabienne Abraham, Nathalie Sebaoun, Jean-Marc de Lamballerie, Xavier Charrel, Remi Souty, Cecile Camara, Ibrahima Pergeline, Jeanne Noël, Harold Guerrisi, Caroline van der Werf, Sylvie Carrat, Fabrice Hanslik, Thomas Blanchon, Thierry Falchi, Alessandra |
author_sort | Pouquet, Marie |
collection | PubMed |
description | Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan France. Methods: Here, we propose a protocol for a nationwide survey to determine the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection in four PHCW populations (general practitioners, pediatricians, pharmacists and assistants, and dentists and assistants) and their household contacts. Participants will be included from June to July 2021 (Phase 1) among PHCW populations located throughout metropolitan France. They will be asked to provide a range of demographic and behavioral information since the first SARS-CoV-2 wave and a self-sampled dried blood spot. Phase 1 will involve also a questionnaire and serological study of PHCWs’ household contacts. Seroprevalence will be estimated using two ELISAs designed to detect specific IgG antibodies to SARS-CoV-2 in humoral fluid, and these results will be confirmed using a virus neutralization test. This study will be repeated from November to December 2021 (Phase 2) to evaluate the evolution of immune status achieved by vaccination and/or natural protection of PHCWs and to describe the history of exposure to SARS-CoV-2. |
format | Online Article Text |
id | pubmed-8308883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83088832021-07-25 Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol Pouquet, Marie Decarreaux, Dorine Prévot-Monsacré, Pol Hervé, Corentin Werner, Andréas Grosgogeat, Brigitte Blanché, Hélène Rabiega, Pascaline Laupie, Julien Kochert, Fabienne Abraham, Nathalie Sebaoun, Jean-Marc de Lamballerie, Xavier Charrel, Remi Souty, Cecile Camara, Ibrahima Pergeline, Jeanne Noël, Harold Guerrisi, Caroline van der Werf, Sylvie Carrat, Fabrice Hanslik, Thomas Blanchon, Thierry Falchi, Alessandra Pathogens Study Protocol Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (PHCWs) and their household contacts in metropolitan France. Methods: Here, we propose a protocol for a nationwide survey to determine the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection in four PHCW populations (general practitioners, pediatricians, pharmacists and assistants, and dentists and assistants) and their household contacts. Participants will be included from June to July 2021 (Phase 1) among PHCW populations located throughout metropolitan France. They will be asked to provide a range of demographic and behavioral information since the first SARS-CoV-2 wave and a self-sampled dried blood spot. Phase 1 will involve also a questionnaire and serological study of PHCWs’ household contacts. Seroprevalence will be estimated using two ELISAs designed to detect specific IgG antibodies to SARS-CoV-2 in humoral fluid, and these results will be confirmed using a virus neutralization test. This study will be repeated from November to December 2021 (Phase 2) to evaluate the evolution of immune status achieved by vaccination and/or natural protection of PHCWs and to describe the history of exposure to SARS-CoV-2. MDPI 2021-07-20 /pmc/articles/PMC8308883/ /pubmed/34358061 http://dx.doi.org/10.3390/pathogens10070911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Study Protocol Pouquet, Marie Decarreaux, Dorine Prévot-Monsacré, Pol Hervé, Corentin Werner, Andréas Grosgogeat, Brigitte Blanché, Hélène Rabiega, Pascaline Laupie, Julien Kochert, Fabienne Abraham, Nathalie Sebaoun, Jean-Marc de Lamballerie, Xavier Charrel, Remi Souty, Cecile Camara, Ibrahima Pergeline, Jeanne Noël, Harold Guerrisi, Caroline van der Werf, Sylvie Carrat, Fabrice Hanslik, Thomas Blanchon, Thierry Falchi, Alessandra Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title | Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title_full | Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title_fullStr | Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title_full_unstemmed | Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title_short | Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol |
title_sort | nationwide seroprevalence of sars-cov-2 igg antibodies among four groups of primary health-care workers and their household contacts 6 months after the initiation of the covid-19 vaccination campaign in france: seroprim study protocol |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308883/ https://www.ncbi.nlm.nih.gov/pubmed/34358061 http://dx.doi.org/10.3390/pathogens10070911 |
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