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Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurren...

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Autores principales: Zhu, Chaojie, Ji, Zhiheng, Ma, Junkai, Ding, Zhijie, Shen, Jie, Wang, Qiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308943/
https://www.ncbi.nlm.nih.gov/pubmed/34202452
http://dx.doi.org/10.3390/pharmaceutics13070940
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author Zhu, Chaojie
Ji, Zhiheng
Ma, Junkai
Ding, Zhijie
Shen, Jie
Wang, Qiwen
author_facet Zhu, Chaojie
Ji, Zhiheng
Ma, Junkai
Ding, Zhijie
Shen, Jie
Wang, Qiwen
author_sort Zhu, Chaojie
collection PubMed
description Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.
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spelling pubmed-83089432021-07-25 Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment Zhu, Chaojie Ji, Zhiheng Ma, Junkai Ding, Zhijie Shen, Jie Wang, Qiwen Pharmaceutics Review Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field. MDPI 2021-06-24 /pmc/articles/PMC8308943/ /pubmed/34202452 http://dx.doi.org/10.3390/pharmaceutics13070940 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Chaojie
Ji, Zhiheng
Ma, Junkai
Ding, Zhijie
Shen, Jie
Wang, Qiwen
Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title_full Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title_fullStr Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title_full_unstemmed Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title_short Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
title_sort recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308943/
https://www.ncbi.nlm.nih.gov/pubmed/34202452
http://dx.doi.org/10.3390/pharmaceutics13070940
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