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A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy

Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug efflux and the effects of exosome inhibition. The experiment...

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Detalles Bibliográficos
Autores principales:	Wang, Jin, Yeung, Bertrand Z., Wientjes, M. Guillaume, Cui, Minjian, Peer, Cody J., Lu, Ze, Figg, William D., Woo, Sukyung, Au, Jessie L.-S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308960/ https://www.ncbi.nlm.nih.gov/pubmed/34209265 http://dx.doi.org/10.3390/pharmaceutics13070997

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