Cargando…

Cell-Penetrating Peptides and Transportan

In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostal...

Descripción completa

Detalles Bibliográficos
Autor principal: Langel, Ülo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308968/
https://www.ncbi.nlm.nih.gov/pubmed/34210007
http://dx.doi.org/10.3390/pharmaceutics13070987
_version_ 1783728410625835008
author Langel, Ülo
author_facet Langel, Ülo
author_sort Langel, Ülo
collection PubMed
description In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc.
format Online
Article
Text
id pubmed-8308968
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83089682021-07-25 Cell-Penetrating Peptides and Transportan Langel, Ülo Pharmaceutics Review In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc. MDPI 2021-06-29 /pmc/articles/PMC8308968/ /pubmed/34210007 http://dx.doi.org/10.3390/pharmaceutics13070987 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Langel, Ülo
Cell-Penetrating Peptides and Transportan
title Cell-Penetrating Peptides and Transportan
title_full Cell-Penetrating Peptides and Transportan
title_fullStr Cell-Penetrating Peptides and Transportan
title_full_unstemmed Cell-Penetrating Peptides and Transportan
title_short Cell-Penetrating Peptides and Transportan
title_sort cell-penetrating peptides and transportan
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308968/
https://www.ncbi.nlm.nih.gov/pubmed/34210007
http://dx.doi.org/10.3390/pharmaceutics13070987
work_keys_str_mv AT langelulo cellpenetratingpeptidesandtransportan