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Cell-Penetrating Peptides and Transportan
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308968/ https://www.ncbi.nlm.nih.gov/pubmed/34210007 http://dx.doi.org/10.3390/pharmaceutics13070987 |
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author | Langel, Ülo |
author_facet | Langel, Ülo |
author_sort | Langel, Ülo |
collection | PubMed |
description | In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc. |
format | Online Article Text |
id | pubmed-8308968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83089682021-07-25 Cell-Penetrating Peptides and Transportan Langel, Ülo Pharmaceutics Review In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc. MDPI 2021-06-29 /pmc/articles/PMC8308968/ /pubmed/34210007 http://dx.doi.org/10.3390/pharmaceutics13070987 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Langel, Ülo Cell-Penetrating Peptides and Transportan |
title | Cell-Penetrating Peptides and Transportan |
title_full | Cell-Penetrating Peptides and Transportan |
title_fullStr | Cell-Penetrating Peptides and Transportan |
title_full_unstemmed | Cell-Penetrating Peptides and Transportan |
title_short | Cell-Penetrating Peptides and Transportan |
title_sort | cell-penetrating peptides and transportan |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308968/ https://www.ncbi.nlm.nih.gov/pubmed/34210007 http://dx.doi.org/10.3390/pharmaceutics13070987 |
work_keys_str_mv | AT langelulo cellpenetratingpeptidesandtransportan |