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Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM
Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308980/ https://www.ncbi.nlm.nih.gov/pubmed/34201853 http://dx.doi.org/10.3390/pharmaceutics13070937 |
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author | Bhonsale, Satyajeet Scott, Lewis Ghadiri, Mojtaba Van Impe, Jan |
author_facet | Bhonsale, Satyajeet Scott, Lewis Ghadiri, Mojtaba Van Impe, Jan |
author_sort | Bhonsale, Satyajeet |
collection | PubMed |
description | Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the particle phase. In this study, we investigate particle dynamics in a 50-mm spiral jet mill through coupled CFD-DEM simulations. The simulations showed that the fluid was significantly decelerated by the presence of the particles in the milling chamber. Furthermore, we study the particle dynamics and collision statistics at two different operating conditions and three different particle loadings. As expected, the particle velocity was affected by both the particle loading and operating pressure. The particles moved slower at low pressures and high loadings. We also found that particle–particle collisions outnumbered particle–wall collisions. |
format | Online Article Text |
id | pubmed-8308980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83089802021-07-25 Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM Bhonsale, Satyajeet Scott, Lewis Ghadiri, Mojtaba Van Impe, Jan Pharmaceutics Article Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the particle phase. In this study, we investigate particle dynamics in a 50-mm spiral jet mill through coupled CFD-DEM simulations. The simulations showed that the fluid was significantly decelerated by the presence of the particles in the milling chamber. Furthermore, we study the particle dynamics and collision statistics at two different operating conditions and three different particle loadings. As expected, the particle velocity was affected by both the particle loading and operating pressure. The particles moved slower at low pressures and high loadings. We also found that particle–particle collisions outnumbered particle–wall collisions. MDPI 2021-06-23 /pmc/articles/PMC8308980/ /pubmed/34201853 http://dx.doi.org/10.3390/pharmaceutics13070937 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bhonsale, Satyajeet Scott, Lewis Ghadiri, Mojtaba Van Impe, Jan Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title | Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title_full | Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title_fullStr | Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title_full_unstemmed | Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title_short | Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM |
title_sort | numerical simulation of particle dynamics in a spiral jet mill via coupled cfd-dem |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308980/ https://www.ncbi.nlm.nih.gov/pubmed/34201853 http://dx.doi.org/10.3390/pharmaceutics13070937 |
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