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Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019

Choline kinase alpha (CHKA) is a promising target for the development of cancer therapeutics. We have previously reported ICL-CCIC-0019, a potent CHKA inhibitor with high cellular activity but with some unfavorable pharmacological properties. In this work, we present an active analogue of ICL-CCIC-0...

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Detalles Bibliográficos
Autores principales:	Wang, Ning, Brickute, Diana, Braga, Marta, Barnes, Chris, Lu, Haonan, Allott, Louis, Aboagye, Eric O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309005/ https://www.ncbi.nlm.nih.gov/pubmed/34371769 http://dx.doi.org/10.3390/pharmaceutics13071078

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