Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of (18)F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process,...

Descripción completa

Detalles Bibliográficos
Autores principales: Gower-Fry, Lexi, Kronemann, Travis, Dorian, Andreas, Pu, Yinglan, Jaworski, Carolin, Wängler, Carmen, Bartenstein, Peter, Beyer, Leonie, Lindner, Simon, Jurkschat, Klaus, Wängler, Björn, Bailey, Justin J., Schirrmacher, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309031/
https://www.ncbi.nlm.nih.gov/pubmed/34358127
http://dx.doi.org/10.3390/ph14070701
Descripción
Sumario:The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of (18)F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [(18)F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [(18)F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.

Ejemplares similares