Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of (18)F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process,...

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Autores principales: Gower-Fry, Lexi, Kronemann, Travis, Dorian, Andreas, Pu, Yinglan, Jaworski, Carolin, Wängler, Carmen, Bartenstein, Peter, Beyer, Leonie, Lindner, Simon, Jurkschat, Klaus, Wängler, Björn, Bailey, Justin J., Schirrmacher, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309031/
https://www.ncbi.nlm.nih.gov/pubmed/34358127
http://dx.doi.org/10.3390/ph14070701
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author Gower-Fry, Lexi
Kronemann, Travis
Dorian, Andreas
Pu, Yinglan
Jaworski, Carolin
Wängler, Carmen
Bartenstein, Peter
Beyer, Leonie
Lindner, Simon
Jurkschat, Klaus
Wängler, Björn
Bailey, Justin J.
Schirrmacher, Ralf
author_facet Gower-Fry, Lexi
Kronemann, Travis
Dorian, Andreas
Pu, Yinglan
Jaworski, Carolin
Wängler, Carmen
Bartenstein, Peter
Beyer, Leonie
Lindner, Simon
Jurkschat, Klaus
Wängler, Björn
Bailey, Justin J.
Schirrmacher, Ralf
author_sort Gower-Fry, Lexi
collection PubMed
description The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of (18)F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [(18)F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [(18)F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.
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spelling pubmed-83090312021-07-25 Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals Gower-Fry, Lexi Kronemann, Travis Dorian, Andreas Pu, Yinglan Jaworski, Carolin Wängler, Carmen Bartenstein, Peter Beyer, Leonie Lindner, Simon Jurkschat, Klaus Wängler, Björn Bailey, Justin J. Schirrmacher, Ralf Pharmaceuticals (Basel) Review The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of (18)F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [(18)F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [(18)F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use. MDPI 2021-07-20 /pmc/articles/PMC8309031/ /pubmed/34358127 http://dx.doi.org/10.3390/ph14070701 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gower-Fry, Lexi
Kronemann, Travis
Dorian, Andreas
Pu, Yinglan
Jaworski, Carolin
Wängler, Carmen
Bartenstein, Peter
Beyer, Leonie
Lindner, Simon
Jurkschat, Klaus
Wängler, Björn
Bailey, Justin J.
Schirrmacher, Ralf
Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title_full Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title_fullStr Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title_full_unstemmed Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title_short Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) (18)F-Radiopharmaceuticals
title_sort recent advances in the clinical translation of silicon fluoride acceptor (sifa) (18)f-radiopharmaceuticals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309031/
https://www.ncbi.nlm.nih.gov/pubmed/34358127
http://dx.doi.org/10.3390/ph14070701
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