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Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0....

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Autores principales: Uney, Kamil, Durna Corum, Duygu, Terzi, Ertugrul, Corum, Orhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309133/
https://www.ncbi.nlm.nih.gov/pubmed/34208822
http://dx.doi.org/10.3390/pharmaceutics13070990
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author Uney, Kamil
Durna Corum, Duygu
Terzi, Ertugrul
Corum, Orhan
author_facet Uney, Kamil
Durna Corum, Duygu
Terzi, Ertugrul
Corum, Orhan
author_sort Uney, Kamil
collection PubMed
description The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t(1/2λz)) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (C(max)) was 3.96 and 2.52 μg/mL with the time to reach C(max) of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t(1/2λz) for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock.
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spelling pubmed-83091332021-07-25 Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock Uney, Kamil Durna Corum, Duygu Terzi, Ertugrul Corum, Orhan Pharmaceutics Article The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t(1/2λz)) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (C(max)) was 3.96 and 2.52 μg/mL with the time to reach C(max) of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t(1/2λz) for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock. MDPI 2021-06-30 /pmc/articles/PMC8309133/ /pubmed/34208822 http://dx.doi.org/10.3390/pharmaceutics13070990 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uney, Kamil
Durna Corum, Duygu
Terzi, Ertugrul
Corum, Orhan
Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title_full Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title_fullStr Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title_full_unstemmed Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title_short Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
title_sort pharmacokinetics and bioavailability of carprofen in rainbow trout (oncorhynchus mykiss) broodstock
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309133/
https://www.ncbi.nlm.nih.gov/pubmed/34208822
http://dx.doi.org/10.3390/pharmaceutics13070990
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