Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone

West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Her...

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Autores principales: Li, Guohua, Meng, Xianyong, Ren, Zhiguang, Li, Entao, Yan, Feihu, Liu, Jing, Zhang, Ying, Cui, Zhanding, Li, Yuetao, Jin, Hongli, Cao, Zengguo, Yi, Le, Huang, Pei, Chi, Hang, Wang, Hualei, Sun, Weiyang, Wang, Tiecheng, Gao, Yuwei, Zhao, Yongkun, Yang, Songtao, Xia, Xianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309971/
https://www.ncbi.nlm.nih.gov/pubmed/34209472
http://dx.doi.org/10.3390/v13071262
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author Li, Guohua
Meng, Xianyong
Ren, Zhiguang
Li, Entao
Yan, Feihu
Liu, Jing
Zhang, Ying
Cui, Zhanding
Li, Yuetao
Jin, Hongli
Cao, Zengguo
Yi, Le
Huang, Pei
Chi, Hang
Wang, Hualei
Sun, Weiyang
Wang, Tiecheng
Gao, Yuwei
Zhao, Yongkun
Yang, Songtao
Xia, Xianzhu
author_facet Li, Guohua
Meng, Xianyong
Ren, Zhiguang
Li, Entao
Yan, Feihu
Liu, Jing
Zhang, Ying
Cui, Zhanding
Li, Yuetao
Jin, Hongli
Cao, Zengguo
Yi, Le
Huang, Pei
Chi, Hang
Wang, Hualei
Sun, Weiyang
Wang, Tiecheng
Gao, Yuwei
Zhao, Yongkun
Yang, Songtao
Xia, Xianzhu
author_sort Li, Guohua
collection PubMed
description West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prMΔE gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.
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spelling pubmed-83099712021-07-25 Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone Li, Guohua Meng, Xianyong Ren, Zhiguang Li, Entao Yan, Feihu Liu, Jing Zhang, Ying Cui, Zhanding Li, Yuetao Jin, Hongli Cao, Zengguo Yi, Le Huang, Pei Chi, Hang Wang, Hualei Sun, Weiyang Wang, Tiecheng Gao, Yuwei Zhao, Yongkun Yang, Songtao Xia, Xianzhu Viruses Article West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prMΔE gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice. MDPI 2021-06-29 /pmc/articles/PMC8309971/ /pubmed/34209472 http://dx.doi.org/10.3390/v13071262 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Guohua
Meng, Xianyong
Ren, Zhiguang
Li, Entao
Yan, Feihu
Liu, Jing
Zhang, Ying
Cui, Zhanding
Li, Yuetao
Jin, Hongli
Cao, Zengguo
Yi, Le
Huang, Pei
Chi, Hang
Wang, Hualei
Sun, Weiyang
Wang, Tiecheng
Gao, Yuwei
Zhao, Yongkun
Yang, Songtao
Xia, Xianzhu
Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title_full Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title_fullStr Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title_full_unstemmed Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title_short Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
title_sort characteristics of chimeric west nile virus based on the japanese encephalitis virus sa14-14-2 backbone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309971/
https://www.ncbi.nlm.nih.gov/pubmed/34209472
http://dx.doi.org/10.3390/v13071262
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