Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy

Adeno-associated virus (AAV) was first characterized as small “defective” contaminant particles in a simian adenovirus preparation in 1965. Since then, a recombinant platform of AAV (rAAV) has become one of the leading candidates for gene therapy applications resulting in two FDA-approved treatments...

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Autores principales: Bower, Jacquelyn J., Song, Liujiang, Bastola, Prabhakar, Hirsch, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309980/
https://www.ncbi.nlm.nih.gov/pubmed/34201599
http://dx.doi.org/10.3390/v13071205
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author Bower, Jacquelyn J.
Song, Liujiang
Bastola, Prabhakar
Hirsch, Matthew L.
author_facet Bower, Jacquelyn J.
Song, Liujiang
Bastola, Prabhakar
Hirsch, Matthew L.
author_sort Bower, Jacquelyn J.
collection PubMed
description Adeno-associated virus (AAV) was first characterized as small “defective” contaminant particles in a simian adenovirus preparation in 1965. Since then, a recombinant platform of AAV (rAAV) has become one of the leading candidates for gene therapy applications resulting in two FDA-approved treatments for rare monogenic diseases and many more currently in various phases of the pharmaceutical development pipeline. Herein, we summarize rAAV approaches for the treatment of diverse types of cancers and highlight the natural anti-oncogenic effects of wild-type AAV (wtAAV), including interactions with the cellular host machinery, that are of relevance to enhance current treatment strategies for cancer.
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spelling pubmed-83099802021-07-25 Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy Bower, Jacquelyn J. Song, Liujiang Bastola, Prabhakar Hirsch, Matthew L. Viruses Review Adeno-associated virus (AAV) was first characterized as small “defective” contaminant particles in a simian adenovirus preparation in 1965. Since then, a recombinant platform of AAV (rAAV) has become one of the leading candidates for gene therapy applications resulting in two FDA-approved treatments for rare monogenic diseases and many more currently in various phases of the pharmaceutical development pipeline. Herein, we summarize rAAV approaches for the treatment of diverse types of cancers and highlight the natural anti-oncogenic effects of wild-type AAV (wtAAV), including interactions with the cellular host machinery, that are of relevance to enhance current treatment strategies for cancer. MDPI 2021-06-23 /pmc/articles/PMC8309980/ /pubmed/34201599 http://dx.doi.org/10.3390/v13071205 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bower, Jacquelyn J.
Song, Liujiang
Bastola, Prabhakar
Hirsch, Matthew L.
Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title_full Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title_fullStr Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title_full_unstemmed Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title_short Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
title_sort harnessing the natural biology of adeno-associated virus to enhance the efficacy of cancer gene therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309980/
https://www.ncbi.nlm.nih.gov/pubmed/34201599
http://dx.doi.org/10.3390/v13071205
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