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Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI

Background: The first goal of the study was to analyse the antibody titre 21 days after the first dose of the BNT162b2 vaccine in a group of 252 healthcare workers (HCW). The second goal was to analyse how the antibody titre changes in correlation with age, gender and body mass index (BMI). Methods:...

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Autores principales: Pellini, Raul, Venuti, Aldo, Pimpinelli, Fulvia, Abril, Elva, Blandino, Giovanni, Campo, Flaminia, Conti, Laura, De Virgilio, Armando, De Marco, Federico, Di Domenico, Enea Gino, Di Bella, Ornella, Di Martino, Simona, Ensoli, Fabrizio, Giannarelli, Diana, Mandoj, Chiara, Manciocco, Valentina, Marchesi, Paolo, Mazzola, Francesco, Moretto, Silvia, Petruzzi, Gerardo, Petrone, Fabrizio, Pichi, Barbara, Pontone, Martina, Zocchi, Jacopo, Vidiri, Antonello, Vujovic, Branka, Piaggio, Giulia, Morrone, Aldo, Ciliberto, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310011/
https://www.ncbi.nlm.nih.gov/pubmed/34206312
http://dx.doi.org/10.3390/vaccines9070685
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author Pellini, Raul
Venuti, Aldo
Pimpinelli, Fulvia
Abril, Elva
Blandino, Giovanni
Campo, Flaminia
Conti, Laura
De Virgilio, Armando
De Marco, Federico
Di Domenico, Enea Gino
Di Bella, Ornella
Di Martino, Simona
Ensoli, Fabrizio
Giannarelli, Diana
Mandoj, Chiara
Manciocco, Valentina
Marchesi, Paolo
Mazzola, Francesco
Moretto, Silvia
Petruzzi, Gerardo
Petrone, Fabrizio
Pichi, Barbara
Pontone, Martina
Zocchi, Jacopo
Vidiri, Antonello
Vujovic, Branka
Piaggio, Giulia
Morrone, Aldo
Ciliberto, Gennaro
author_facet Pellini, Raul
Venuti, Aldo
Pimpinelli, Fulvia
Abril, Elva
Blandino, Giovanni
Campo, Flaminia
Conti, Laura
De Virgilio, Armando
De Marco, Federico
Di Domenico, Enea Gino
Di Bella, Ornella
Di Martino, Simona
Ensoli, Fabrizio
Giannarelli, Diana
Mandoj, Chiara
Manciocco, Valentina
Marchesi, Paolo
Mazzola, Francesco
Moretto, Silvia
Petruzzi, Gerardo
Petrone, Fabrizio
Pichi, Barbara
Pontone, Martina
Zocchi, Jacopo
Vidiri, Antonello
Vujovic, Branka
Piaggio, Giulia
Morrone, Aldo
Ciliberto, Gennaro
author_sort Pellini, Raul
collection PubMed
description Background: The first goal of the study was to analyse the antibody titre 21 days after the first dose of the BNT162b2 vaccine in a group of 252 healthcare workers (HCW). The second goal was to analyse how the antibody titre changes in correlation with age, gender and body mass index (BMI). Methods: Participants had a nasopharyngeal swab for SARS-CoV-2 and were assessed for the presence of SARS-CoV-2 antibodies at baseline and 21 days after the BNT162b2 priming dose. Results: First dose of BNT162b2 activated immune responses in 98% of the participants. Five HWC had no increase in antibody titre 21 days after the first dose. Antibody titre was greater in young (<38 years) vs. older participants (<38 vs. 47–56 p = 0.002; <38 vs. >56 p = 0.001). Higher antibody levels were detected in underweight vs. pre-obesity group (p = 0.026) and in normal-weight vs. pre-obesity group (p = 0.007). This association was confirmed after adjusting for age (p = 0.0001) and gender (p = 0.00001). Conclusions: Our study demonstrates that a single dose of BNT162b2 activates the immune response, and being young and normal-weight correlate positively with this response. Larger specifically designed clinical trials are needed to validate these results.
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spelling pubmed-83100112021-07-25 Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI Pellini, Raul Venuti, Aldo Pimpinelli, Fulvia Abril, Elva Blandino, Giovanni Campo, Flaminia Conti, Laura De Virgilio, Armando De Marco, Federico Di Domenico, Enea Gino Di Bella, Ornella Di Martino, Simona Ensoli, Fabrizio Giannarelli, Diana Mandoj, Chiara Manciocco, Valentina Marchesi, Paolo Mazzola, Francesco Moretto, Silvia Petruzzi, Gerardo Petrone, Fabrizio Pichi, Barbara Pontone, Martina Zocchi, Jacopo Vidiri, Antonello Vujovic, Branka Piaggio, Giulia Morrone, Aldo Ciliberto, Gennaro Vaccines (Basel) Brief Report Background: The first goal of the study was to analyse the antibody titre 21 days after the first dose of the BNT162b2 vaccine in a group of 252 healthcare workers (HCW). The second goal was to analyse how the antibody titre changes in correlation with age, gender and body mass index (BMI). Methods: Participants had a nasopharyngeal swab for SARS-CoV-2 and were assessed for the presence of SARS-CoV-2 antibodies at baseline and 21 days after the BNT162b2 priming dose. Results: First dose of BNT162b2 activated immune responses in 98% of the participants. Five HWC had no increase in antibody titre 21 days after the first dose. Antibody titre was greater in young (<38 years) vs. older participants (<38 vs. 47–56 p = 0.002; <38 vs. >56 p = 0.001). Higher antibody levels were detected in underweight vs. pre-obesity group (p = 0.026) and in normal-weight vs. pre-obesity group (p = 0.007). This association was confirmed after adjusting for age (p = 0.0001) and gender (p = 0.00001). Conclusions: Our study demonstrates that a single dose of BNT162b2 activates the immune response, and being young and normal-weight correlate positively with this response. Larger specifically designed clinical trials are needed to validate these results. MDPI 2021-06-22 /pmc/articles/PMC8310011/ /pubmed/34206312 http://dx.doi.org/10.3390/vaccines9070685 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Pellini, Raul
Venuti, Aldo
Pimpinelli, Fulvia
Abril, Elva
Blandino, Giovanni
Campo, Flaminia
Conti, Laura
De Virgilio, Armando
De Marco, Federico
Di Domenico, Enea Gino
Di Bella, Ornella
Di Martino, Simona
Ensoli, Fabrizio
Giannarelli, Diana
Mandoj, Chiara
Manciocco, Valentina
Marchesi, Paolo
Mazzola, Francesco
Moretto, Silvia
Petruzzi, Gerardo
Petrone, Fabrizio
Pichi, Barbara
Pontone, Martina
Zocchi, Jacopo
Vidiri, Antonello
Vujovic, Branka
Piaggio, Giulia
Morrone, Aldo
Ciliberto, Gennaro
Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title_full Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title_fullStr Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title_full_unstemmed Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title_short Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI
title_sort early onset of sars-cov-2 antibodies after first dose of bnt162b2: correlation with age, gender and bmi
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310011/
https://www.ncbi.nlm.nih.gov/pubmed/34206312
http://dx.doi.org/10.3390/vaccines9070685
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