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Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection

Latent varicella zoster virus (VZV) has been detected in human adrenal glands, raising the possibility of virus-induced adrenal damage and dysfunction during primary infection or reactivation. Rare cases of bilateral adrenal hemorrhage and insufficiency associated with VZV reactivation have been rep...

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Autores principales: Niemeyer, Christy S., Mescher, Teresa, Griggs, Rocio, Orlicky, David J., Wilkerson, Gregory K., Bubak, Andrew N., Hassell, James E., Feia, Brittany, Mahalingam, Ravi, Traina-Dorge, Vicki, Nagel, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310062/
https://www.ncbi.nlm.nih.gov/pubmed/34206909
http://dx.doi.org/10.3390/v13071245
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author Niemeyer, Christy S.
Mescher, Teresa
Griggs, Rocio
Orlicky, David J.
Wilkerson, Gregory K.
Bubak, Andrew N.
Hassell, James E.
Feia, Brittany
Mahalingam, Ravi
Traina-Dorge, Vicki
Nagel, Maria A.
author_facet Niemeyer, Christy S.
Mescher, Teresa
Griggs, Rocio
Orlicky, David J.
Wilkerson, Gregory K.
Bubak, Andrew N.
Hassell, James E.
Feia, Brittany
Mahalingam, Ravi
Traina-Dorge, Vicki
Nagel, Maria A.
author_sort Niemeyer, Christy S.
collection PubMed
description Latent varicella zoster virus (VZV) has been detected in human adrenal glands, raising the possibility of virus-induced adrenal damage and dysfunction during primary infection or reactivation. Rare cases of bilateral adrenal hemorrhage and insufficiency associated with VZV reactivation have been reported. Since there is no animal model for VZV infection of adrenal glands, we obtained adrenal glands from two non-human primates (NHPs) that spontaneously developed varicella from primary simian varicella virus (SVV) infection, the NHP VZV homolog. Histological and immunohistochemical analysis revealed SVV antigen and DNA in the adrenal medulla and cortex of both animals. Adrenal glands were observed to have Cowdry A inclusion bodies, cellular necrosis, multiple areas of hemorrhage, and varying amounts of polymorphonuclear cells. No specific association of SVV antigen with βIII-tubulin-positive nerve fibers was found. Overall, we found that SVV can productively infect NHP adrenal glands, and is associated with inflammation, hemorrhage, and cell death. These findings suggest that further studies are warranted to examine the contribution of VZV infection to human adrenal disease. This study also suggests that VZV infection may present itself as acute adrenal dysfunction with “long-hauler” symptoms of fatigue, weakness, myalgias/arthralgias, and hypotension.
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spelling pubmed-83100622021-07-25 Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection Niemeyer, Christy S. Mescher, Teresa Griggs, Rocio Orlicky, David J. Wilkerson, Gregory K. Bubak, Andrew N. Hassell, James E. Feia, Brittany Mahalingam, Ravi Traina-Dorge, Vicki Nagel, Maria A. Viruses Article Latent varicella zoster virus (VZV) has been detected in human adrenal glands, raising the possibility of virus-induced adrenal damage and dysfunction during primary infection or reactivation. Rare cases of bilateral adrenal hemorrhage and insufficiency associated with VZV reactivation have been reported. Since there is no animal model for VZV infection of adrenal glands, we obtained adrenal glands from two non-human primates (NHPs) that spontaneously developed varicella from primary simian varicella virus (SVV) infection, the NHP VZV homolog. Histological and immunohistochemical analysis revealed SVV antigen and DNA in the adrenal medulla and cortex of both animals. Adrenal glands were observed to have Cowdry A inclusion bodies, cellular necrosis, multiple areas of hemorrhage, and varying amounts of polymorphonuclear cells. No specific association of SVV antigen with βIII-tubulin-positive nerve fibers was found. Overall, we found that SVV can productively infect NHP adrenal glands, and is associated with inflammation, hemorrhage, and cell death. These findings suggest that further studies are warranted to examine the contribution of VZV infection to human adrenal disease. This study also suggests that VZV infection may present itself as acute adrenal dysfunction with “long-hauler” symptoms of fatigue, weakness, myalgias/arthralgias, and hypotension. MDPI 2021-06-26 /pmc/articles/PMC8310062/ /pubmed/34206909 http://dx.doi.org/10.3390/v13071245 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Niemeyer, Christy S.
Mescher, Teresa
Griggs, Rocio
Orlicky, David J.
Wilkerson, Gregory K.
Bubak, Andrew N.
Hassell, James E.
Feia, Brittany
Mahalingam, Ravi
Traina-Dorge, Vicki
Nagel, Maria A.
Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title_full Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title_fullStr Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title_full_unstemmed Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title_short Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection
title_sort histopathological analysis of adrenal glands after simian varicella virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310062/
https://www.ncbi.nlm.nih.gov/pubmed/34206909
http://dx.doi.org/10.3390/v13071245
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