Clinical Applications and Immunological Aspects of Electroporation-Based Therapies

Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medic...

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Autores principales: da Luz, Jean Carlos dos Santos, Antunes, Fernanda, Clavijo-Salomon, Maria Alejandra, Signori, Emanuela, Tessarollo, Nayara Gusmão, Strauss, Bryan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310106/
https://www.ncbi.nlm.nih.gov/pubmed/34358144
http://dx.doi.org/10.3390/vaccines9070727
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author da Luz, Jean Carlos dos Santos
Antunes, Fernanda
Clavijo-Salomon, Maria Alejandra
Signori, Emanuela
Tessarollo, Nayara Gusmão
Strauss, Bryan E.
author_facet da Luz, Jean Carlos dos Santos
Antunes, Fernanda
Clavijo-Salomon, Maria Alejandra
Signori, Emanuela
Tessarollo, Nayara Gusmão
Strauss, Bryan E.
author_sort da Luz, Jean Carlos dos Santos
collection PubMed
description Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunological aspects involved in electrochemotherapy and gene electrotransfer, two important EP-based cancer therapies in human and veterinary oncology.
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spelling pubmed-83101062021-07-25 Clinical Applications and Immunological Aspects of Electroporation-Based Therapies da Luz, Jean Carlos dos Santos Antunes, Fernanda Clavijo-Salomon, Maria Alejandra Signori, Emanuela Tessarollo, Nayara Gusmão Strauss, Bryan E. Vaccines (Basel) Review Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently used in a variety of applications, from medicine to food processing. In oncology, RE is applied for the intracellular transport of chemotherapeutic drugs as well as the delivery of genetic material in gene therapies and vaccinations. This review summarizes the physical changes of the membrane, the particularities of bleomycin, and the immunological aspects involved in electrochemotherapy and gene electrotransfer, two important EP-based cancer therapies in human and veterinary oncology. MDPI 2021-07-02 /pmc/articles/PMC8310106/ /pubmed/34358144 http://dx.doi.org/10.3390/vaccines9070727 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
da Luz, Jean Carlos dos Santos
Antunes, Fernanda
Clavijo-Salomon, Maria Alejandra
Signori, Emanuela
Tessarollo, Nayara Gusmão
Strauss, Bryan E.
Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title_full Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title_fullStr Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title_full_unstemmed Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title_short Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
title_sort clinical applications and immunological aspects of electroporation-based therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310106/
https://www.ncbi.nlm.nih.gov/pubmed/34358144
http://dx.doi.org/10.3390/vaccines9070727
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