Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses

Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn, will most likely be a prerequisite for the development of an efficacious p...

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Detalles Bibliográficos
Autores principales: Hauser, Alexandra, Carnell, George, Held, Kathrin, Sulbaran, Guidenn, Tischbierek, Nadine, Rogers, Lisa, Pollakis, Georgios, Tonks, Paul, Hoelscher, Michael, Ding, Song, Sanders, Rogier W., Geldmacher, Christof, Sattentau, Quentin, Weissenhorn, Winfried, Heeney, Jonathan L., Peterhoff, David, Wagner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310183/
https://www.ncbi.nlm.nih.gov/pubmed/34358165
http://dx.doi.org/10.3390/vaccines9070750

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