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Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study

Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enr...

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Autores principales: Baillie, Vicky L., Moore, David P., Mathunjwa, Azwifarwi, Baggett, Henry C., Brooks, Abdullah, Feikin, Daniel R., Hammitt, Laura L., Howie, Stephen R. C., Knoll, Maria Deloria, Kotloff, Karen L., Levine, Orin S., O’Brien, Katherine L., Scott, Anthony G., Thea, Donald M., Antonio, Martin, Awori, Juliet O., Driscoll, Amanda J., Fancourt, Nicholas S. S., Higdon, Melissa M., Karron, Ruth A., Morpeth, Susan C., Mulindwa, Justin M., Murdoch, David R., Park, Daniel E., Prosperi, Christine, Rahman, Mohammed Ziaur, Rahman, Mustafizur, Salaudeen, Rasheed A., Sawatwong, Pongpun, Somwe, Somwe Wa, Sow, Samba O., Tapia, Milagritos D., Simões, Eric A. F., Madhi, Shabir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310211/
https://www.ncbi.nlm.nih.gov/pubmed/34198998
http://dx.doi.org/10.3390/v13071249
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author Baillie, Vicky L.
Moore, David P.
Mathunjwa, Azwifarwi
Baggett, Henry C.
Brooks, Abdullah
Feikin, Daniel R.
Hammitt, Laura L.
Howie, Stephen R. C.
Knoll, Maria Deloria
Kotloff, Karen L.
Levine, Orin S.
O’Brien, Katherine L.
Scott, Anthony G.
Thea, Donald M.
Antonio, Martin
Awori, Juliet O.
Driscoll, Amanda J.
Fancourt, Nicholas S. S.
Higdon, Melissa M.
Karron, Ruth A.
Morpeth, Susan C.
Mulindwa, Justin M.
Murdoch, David R.
Park, Daniel E.
Prosperi, Christine
Rahman, Mohammed Ziaur
Rahman, Mustafizur
Salaudeen, Rasheed A.
Sawatwong, Pongpun
Somwe, Somwe Wa
Sow, Samba O.
Tapia, Milagritos D.
Simões, Eric A. F.
Madhi, Shabir A.
author_facet Baillie, Vicky L.
Moore, David P.
Mathunjwa, Azwifarwi
Baggett, Henry C.
Brooks, Abdullah
Feikin, Daniel R.
Hammitt, Laura L.
Howie, Stephen R. C.
Knoll, Maria Deloria
Kotloff, Karen L.
Levine, Orin S.
O’Brien, Katherine L.
Scott, Anthony G.
Thea, Donald M.
Antonio, Martin
Awori, Juliet O.
Driscoll, Amanda J.
Fancourt, Nicholas S. S.
Higdon, Melissa M.
Karron, Ruth A.
Morpeth, Susan C.
Mulindwa, Justin M.
Murdoch, David R.
Park, Daniel E.
Prosperi, Christine
Rahman, Mohammed Ziaur
Rahman, Mustafizur
Salaudeen, Rasheed A.
Sawatwong, Pongpun
Somwe, Somwe Wa
Sow, Samba O.
Tapia, Milagritos D.
Simões, Eric A. F.
Madhi, Shabir A.
author_sort Baillie, Vicky L.
collection PubMed
description Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1–59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Nasopharyngeal/oropharyngeal swabs were collected for all participants, combined, and tested for RV and 18 other respiratory viruses using the Fast Track multiplex real-time PCR assay. RV detection was more common among cases (24%) than controls (21%) (aOR = 1.5, 95%CI:1.3–1.6). This association was driven by the children aged 12–59 months, where 28% of cases vs. 18% of controls were RV-positive (aOR = 2.1, 95%CI:1.8–2.5). Wheezing was 1.8-fold (aOR 95%CI:1.4–2.2) more prevalent among pneumonia cases who were RV-positive vs. RV-negative. Of the RV-positive cases, 13% had a higher probability (>75%) that RV was the cause of their pneumonia based on the PERCH integrated etiology analysis; 99% of these cases occurred in children over 12 months in Bangladesh. RV was commonly identified in both cases and controls and was significantly associated with severe pneumonia status among children over 12 months of age, particularly those in Bangladesh. RV-positive pneumonia was associated with wheezing.
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spelling pubmed-83102112021-07-25 Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study Baillie, Vicky L. Moore, David P. Mathunjwa, Azwifarwi Baggett, Henry C. Brooks, Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R. C. Knoll, Maria Deloria Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Scott, Anthony G. Thea, Donald M. Antonio, Martin Awori, Juliet O. Driscoll, Amanda J. Fancourt, Nicholas S. S. Higdon, Melissa M. Karron, Ruth A. Morpeth, Susan C. Mulindwa, Justin M. Murdoch, David R. Park, Daniel E. Prosperi, Christine Rahman, Mohammed Ziaur Rahman, Mustafizur Salaudeen, Rasheed A. Sawatwong, Pongpun Somwe, Somwe Wa Sow, Samba O. Tapia, Milagritos D. Simões, Eric A. F. Madhi, Shabir A. Viruses Article Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1–59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Nasopharyngeal/oropharyngeal swabs were collected for all participants, combined, and tested for RV and 18 other respiratory viruses using the Fast Track multiplex real-time PCR assay. RV detection was more common among cases (24%) than controls (21%) (aOR = 1.5, 95%CI:1.3–1.6). This association was driven by the children aged 12–59 months, where 28% of cases vs. 18% of controls were RV-positive (aOR = 2.1, 95%CI:1.8–2.5). Wheezing was 1.8-fold (aOR 95%CI:1.4–2.2) more prevalent among pneumonia cases who were RV-positive vs. RV-negative. Of the RV-positive cases, 13% had a higher probability (>75%) that RV was the cause of their pneumonia based on the PERCH integrated etiology analysis; 99% of these cases occurred in children over 12 months in Bangladesh. RV was commonly identified in both cases and controls and was significantly associated with severe pneumonia status among children over 12 months of age, particularly those in Bangladesh. RV-positive pneumonia was associated with wheezing. MDPI 2021-06-27 /pmc/articles/PMC8310211/ /pubmed/34198998 http://dx.doi.org/10.3390/v13071249 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baillie, Vicky L.
Moore, David P.
Mathunjwa, Azwifarwi
Baggett, Henry C.
Brooks, Abdullah
Feikin, Daniel R.
Hammitt, Laura L.
Howie, Stephen R. C.
Knoll, Maria Deloria
Kotloff, Karen L.
Levine, Orin S.
O’Brien, Katherine L.
Scott, Anthony G.
Thea, Donald M.
Antonio, Martin
Awori, Juliet O.
Driscoll, Amanda J.
Fancourt, Nicholas S. S.
Higdon, Melissa M.
Karron, Ruth A.
Morpeth, Susan C.
Mulindwa, Justin M.
Murdoch, David R.
Park, Daniel E.
Prosperi, Christine
Rahman, Mohammed Ziaur
Rahman, Mustafizur
Salaudeen, Rasheed A.
Sawatwong, Pongpun
Somwe, Somwe Wa
Sow, Samba O.
Tapia, Milagritos D.
Simões, Eric A. F.
Madhi, Shabir A.
Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title_full Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title_fullStr Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title_full_unstemmed Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title_short Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
title_sort epidemiology of the rhinovirus (rv) in african and southeast asian children: a case-control pneumonia etiology study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310211/
https://www.ncbi.nlm.nih.gov/pubmed/34198998
http://dx.doi.org/10.3390/v13071249
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