Cargando…
Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study
Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enr...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310211/ https://www.ncbi.nlm.nih.gov/pubmed/34198998 http://dx.doi.org/10.3390/v13071249 |
_version_ | 1783728706074705920 |
---|---|
author | Baillie, Vicky L. Moore, David P. Mathunjwa, Azwifarwi Baggett, Henry C. Brooks, Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R. C. Knoll, Maria Deloria Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Scott, Anthony G. Thea, Donald M. Antonio, Martin Awori, Juliet O. Driscoll, Amanda J. Fancourt, Nicholas S. S. Higdon, Melissa M. Karron, Ruth A. Morpeth, Susan C. Mulindwa, Justin M. Murdoch, David R. Park, Daniel E. Prosperi, Christine Rahman, Mohammed Ziaur Rahman, Mustafizur Salaudeen, Rasheed A. Sawatwong, Pongpun Somwe, Somwe Wa Sow, Samba O. Tapia, Milagritos D. Simões, Eric A. F. Madhi, Shabir A. |
author_facet | Baillie, Vicky L. Moore, David P. Mathunjwa, Azwifarwi Baggett, Henry C. Brooks, Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R. C. Knoll, Maria Deloria Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Scott, Anthony G. Thea, Donald M. Antonio, Martin Awori, Juliet O. Driscoll, Amanda J. Fancourt, Nicholas S. S. Higdon, Melissa M. Karron, Ruth A. Morpeth, Susan C. Mulindwa, Justin M. Murdoch, David R. Park, Daniel E. Prosperi, Christine Rahman, Mohammed Ziaur Rahman, Mustafizur Salaudeen, Rasheed A. Sawatwong, Pongpun Somwe, Somwe Wa Sow, Samba O. Tapia, Milagritos D. Simões, Eric A. F. Madhi, Shabir A. |
author_sort | Baillie, Vicky L. |
collection | PubMed |
description | Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1–59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Nasopharyngeal/oropharyngeal swabs were collected for all participants, combined, and tested for RV and 18 other respiratory viruses using the Fast Track multiplex real-time PCR assay. RV detection was more common among cases (24%) than controls (21%) (aOR = 1.5, 95%CI:1.3–1.6). This association was driven by the children aged 12–59 months, where 28% of cases vs. 18% of controls were RV-positive (aOR = 2.1, 95%CI:1.8–2.5). Wheezing was 1.8-fold (aOR 95%CI:1.4–2.2) more prevalent among pneumonia cases who were RV-positive vs. RV-negative. Of the RV-positive cases, 13% had a higher probability (>75%) that RV was the cause of their pneumonia based on the PERCH integrated etiology analysis; 99% of these cases occurred in children over 12 months in Bangladesh. RV was commonly identified in both cases and controls and was significantly associated with severe pneumonia status among children over 12 months of age, particularly those in Bangladesh. RV-positive pneumonia was associated with wheezing. |
format | Online Article Text |
id | pubmed-8310211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83102112021-07-25 Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study Baillie, Vicky L. Moore, David P. Mathunjwa, Azwifarwi Baggett, Henry C. Brooks, Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R. C. Knoll, Maria Deloria Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Scott, Anthony G. Thea, Donald M. Antonio, Martin Awori, Juliet O. Driscoll, Amanda J. Fancourt, Nicholas S. S. Higdon, Melissa M. Karron, Ruth A. Morpeth, Susan C. Mulindwa, Justin M. Murdoch, David R. Park, Daniel E. Prosperi, Christine Rahman, Mohammed Ziaur Rahman, Mustafizur Salaudeen, Rasheed A. Sawatwong, Pongpun Somwe, Somwe Wa Sow, Samba O. Tapia, Milagritos D. Simões, Eric A. F. Madhi, Shabir A. Viruses Article Rhinovirus (RV) is commonly detected in asymptomatic children; hence, its pathogenicity during childhood pneumonia remains controversial. We evaluated RV epidemiology in HIV-uninfected children hospitalized with clinical pneumonia and among community controls. PERCH was a case-control study that enrolled children (1–59 months) hospitalized with severe and very severe pneumonia per World Health Organization clinical criteria and age-frequency-matched community controls in seven countries. Nasopharyngeal/oropharyngeal swabs were collected for all participants, combined, and tested for RV and 18 other respiratory viruses using the Fast Track multiplex real-time PCR assay. RV detection was more common among cases (24%) than controls (21%) (aOR = 1.5, 95%CI:1.3–1.6). This association was driven by the children aged 12–59 months, where 28% of cases vs. 18% of controls were RV-positive (aOR = 2.1, 95%CI:1.8–2.5). Wheezing was 1.8-fold (aOR 95%CI:1.4–2.2) more prevalent among pneumonia cases who were RV-positive vs. RV-negative. Of the RV-positive cases, 13% had a higher probability (>75%) that RV was the cause of their pneumonia based on the PERCH integrated etiology analysis; 99% of these cases occurred in children over 12 months in Bangladesh. RV was commonly identified in both cases and controls and was significantly associated with severe pneumonia status among children over 12 months of age, particularly those in Bangladesh. RV-positive pneumonia was associated with wheezing. MDPI 2021-06-27 /pmc/articles/PMC8310211/ /pubmed/34198998 http://dx.doi.org/10.3390/v13071249 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Baillie, Vicky L. Moore, David P. Mathunjwa, Azwifarwi Baggett, Henry C. Brooks, Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R. C. Knoll, Maria Deloria Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Scott, Anthony G. Thea, Donald M. Antonio, Martin Awori, Juliet O. Driscoll, Amanda J. Fancourt, Nicholas S. S. Higdon, Melissa M. Karron, Ruth A. Morpeth, Susan C. Mulindwa, Justin M. Murdoch, David R. Park, Daniel E. Prosperi, Christine Rahman, Mohammed Ziaur Rahman, Mustafizur Salaudeen, Rasheed A. Sawatwong, Pongpun Somwe, Somwe Wa Sow, Samba O. Tapia, Milagritos D. Simões, Eric A. F. Madhi, Shabir A. Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title | Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title_full | Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title_fullStr | Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title_full_unstemmed | Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title_short | Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study |
title_sort | epidemiology of the rhinovirus (rv) in african and southeast asian children: a case-control pneumonia etiology study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310211/ https://www.ncbi.nlm.nih.gov/pubmed/34198998 http://dx.doi.org/10.3390/v13071249 |
work_keys_str_mv | AT baillievickyl epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT mooredavidp epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT mathunjwaazwifarwi epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT baggetthenryc epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT brooksabdullah epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT feikindanielr epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT hammittlaural epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT howiestephenrc epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT knollmariadeloria epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT kotloffkarenl epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT levineorins epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT obrienkatherinel epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT scottanthonyg epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT theadonaldm epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT antoniomartin epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT aworijulieto epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT driscollamandaj epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT fancourtnicholasss epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT higdonmelissam epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT karronrutha epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT morpethsusanc epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT mulindwajustinm epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT murdochdavidr epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT parkdaniele epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT prosperichristine epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT rahmanmohammedziaur epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT rahmanmustafizur epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT salaudeenrasheeda epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT sawatwongpongpun epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT somwesomwewa epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT sowsambao epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT tapiamilagritosd epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT simoesericaf epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy AT madhishabira epidemiologyoftherhinovirusrvinafricanandsoutheastasianchildrenacasecontrolpneumoniaetiologystudy |