Cargando…

Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97

The replication of human cytomegalovirus (HCMV) is characterized by a complex network of virus–host interaction. This involves the regulatory viral protein kinase pUL97, which represents a viral cyclin-dependent kinase ortholog (vCDK) combining typical structural and functional features of host CDKs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schütz, Martin, Steingruber, Mirjam, Socher, Eileen, Müller, Regina, Wagner, Sabrina, Kögel, Merle, Sticht, Heinrich, Marschall, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310212/ https://www.ncbi.nlm.nih.gov/pubmed/34198986 http://dx.doi.org/10.3390/v13071248

Ejemplares similares

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain
por: Steingruber, Mirjam, et al.
Publicado: (2015)

Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins
por: Steingruber, Mirjam, et al.
Publicado: (2016)

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins
por: Graf, Laura, et al.
Publicado: (2013)

The Cytomegalovirus Protein Kinase pUL97: Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting
por: Steingruber, Mirjam, et al.
Publicado: (2020)

Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H
por: Schütz, Martin, et al.
Publicado: (2022)

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
por: Schütz, Martin, et al.
Publicado: (2023)

Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations
por: Wild, Markus, et al.
Publicado: (2022)

Human cytomegaloviral multifunctional protein kinase pUL97 impairs zebrafish embryonic development and increases mortality
por: Cazorla-Vázquez, Salvador, et al.
Publicado: (2019)

Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses
por: Krämer, Nadine, et al.
Publicado: (2022)

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
por: Milbradt, Jens, et al.
Publicado: (2018)

Human Cytomegalovirus Replication Is Strictly Inhibited by siRNAs Targeting UL54, UL97 or UL122/123 Gene Transcripts
por: Hamilton, Stuart T., et al.
Publicado: (2014)

New Insights into Human Cytomegalovirus pUL52 Structure
por: Muller, Clotilde, et al.
Publicado: (2021)

The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus
por: Häge, Sigrun, et al.
Publicado: (2021)

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation
por: Häge, Sigrun, et al.
Publicado: (2021)

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells
por: Wang, Xian-Zhang, et al.
Publicado: (2023)

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex
por: Butt, Benjamin G, et al.
Publicado: (2020)

Serine 13 of the human cytomegalovirus viral cyclin-dependent kinase UL97 is required for regulatory protein 14-3-3 binding and UL97 stability
por: Iwahori, Satoko, et al.
Publicado: (2022)

Cyclin A Degradation by Primate Cytomegalovirus Protein pUL21a Counters Its Innate Restriction of Virus Replication
por: Caffarelli, Nicolas, et al.
Publicado: (2013)

The Cytomegalovirus protein pUL37×1 targets mitochondria to mediate neuroprotection
por: Hong, Chien Tai, et al.
Publicado: (2016)

The contribution of pUL74 to growth of human cytomegalovirus is masked in the presence of RL13 and UL128 expression
por: Laib Sampaio, Kerstin, et al.
Publicado: (2016)

Human Cytomegalovirus-Encoded pUL7 Is a Novel CEACAM1-Like Molecule Responsible for Promotion of Angiogenesis
por: MacManiman, Jason D., et al.
Publicado: (2014)

Human Cytomegalovirus Tegument Protein pUL71 Is Required for Efficient Virion Egress
por: Womack, Andrew, et al.
Publicado: (2010)

Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunit
por: Ligat, G., et al.
Publicado: (2017)

N-Linked Glycosylation and Expression of Duck Plague Virus pUL10 Promoted by pUL49.5
por: Li, Chunmei, et al.
Publicado: (2023)

Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor
por: Fletcher-Etherington, Alice, et al.
Publicado: (2020)

Duck enteritis virus UL21 is a late gene encoding a protein that interacts with pUL16
por: Yang, Linjiang, et al.
Publicado: (2020)

Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection
por: Albecka, Anna, et al.
Publicado: (2017)

Human Cytomegalovirus pUL79 Is an Elongation Factor of RNA Polymerase II for Viral Gene Transcription
por: Perng, Yi-Chieh, et al.
Publicado: (2014)

8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
por: Jung, Eunkyung, et al.
Publicado: (2022)

Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches
por: Almehmadi, Mazen, et al.
Publicado: (2023)

The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein
por: Shannon-Lowe, Claire D, et al.
Publicado: (2010)

Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally
por: Paradowska, Edyta, et al.
Publicado: (2019)

Human Cytomegalovirus Protein pUL117 Targets the Mini-Chromosome Maintenance Complex and Suppresses Cellular DNA Synthesis
por: Qian, Zhikang, et al.
Publicado: (2010)

The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion
por: Zischke, Jasmin, et al.
Publicado: (2017)

Full-length human cytomegalovirus terminase pUL89 adopts a two-domain structure specific for DNA packaging
por: Theiß, Janine, et al.
Publicado: (2019)

Intracellular Trafficking of the Human Cytomegalovirus-Encoded 7-trans-Membrane Protein Homologs pUS27 and pUL78 during Viral Infection: A Comparative Analysis
por: Niemann, Ina, et al.
Publicado: (2014)

Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients
por: Keyvani, Hossein, et al.
Publicado: (2016)

Expression and intracellular localization of duck enteritis virus pUL38 protein
por: Xiang, Jun, et al.
Publicado: (2010)

Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells
por: Osanyinlusi, Samuel A., et al.
Publicado: (2022)

Prevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis
por: Tamura, Satoshi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jcffdi738vq81r93e49bqqbbrr