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Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties

Adenovirus vector-based genetic vaccines have emerged as a powerful strategy against the SARS-CoV-2 health crisis. This success is not unexpected because adenoviruses combine many desirable features of a genetic vaccine. They are highly immunogenic and have a low and well characterized pathogenic pr...

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Detalles Bibliográficos
Autores principales: Daussy, Coralie F., Pied, Noémie, Wodrich, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310329/
https://www.ncbi.nlm.nih.gov/pubmed/34202573
http://dx.doi.org/10.3390/v13071221
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author Daussy, Coralie F.
Pied, Noémie
Wodrich, Harald
author_facet Daussy, Coralie F.
Pied, Noémie
Wodrich, Harald
author_sort Daussy, Coralie F.
collection PubMed
description Adenovirus vector-based genetic vaccines have emerged as a powerful strategy against the SARS-CoV-2 health crisis. This success is not unexpected because adenoviruses combine many desirable features of a genetic vaccine. They are highly immunogenic and have a low and well characterized pathogenic profile paired with technological approachability. Ongoing efforts to improve adenovirus-vaccine vectors include the use of rare serotypes and non-human adenoviruses. In this review, we focus on the viral capsid and how the choice of genotypes influences the uptake and subsequent subcellular sorting. We describe how understanding capsid properties, such as stability during the entry process, can change the fate of the entering particles and how this translates into differences in immunity outcomes. We discuss in detail how mutating the membrane lytic capsid protein VI affects species C viruses’ post-entry sorting and briefly discuss if such approaches could have a wider implication in vaccine and/or vector development.
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spelling pubmed-83103292021-07-25 Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties Daussy, Coralie F. Pied, Noémie Wodrich, Harald Viruses Review Adenovirus vector-based genetic vaccines have emerged as a powerful strategy against the SARS-CoV-2 health crisis. This success is not unexpected because adenoviruses combine many desirable features of a genetic vaccine. They are highly immunogenic and have a low and well characterized pathogenic profile paired with technological approachability. Ongoing efforts to improve adenovirus-vaccine vectors include the use of rare serotypes and non-human adenoviruses. In this review, we focus on the viral capsid and how the choice of genotypes influences the uptake and subsequent subcellular sorting. We describe how understanding capsid properties, such as stability during the entry process, can change the fate of the entering particles and how this translates into differences in immunity outcomes. We discuss in detail how mutating the membrane lytic capsid protein VI affects species C viruses’ post-entry sorting and briefly discuss if such approaches could have a wider implication in vaccine and/or vector development. MDPI 2021-06-24 /pmc/articles/PMC8310329/ /pubmed/34202573 http://dx.doi.org/10.3390/v13071221 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Daussy, Coralie F.
Pied, Noémie
Wodrich, Harald
Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title_full Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title_fullStr Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title_full_unstemmed Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title_short Understanding Post Entry Sorting of Adenovirus Capsids; A Chance to Change Vaccine Vector Properties
title_sort understanding post entry sorting of adenovirus capsids; a chance to change vaccine vector properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310329/
https://www.ncbi.nlm.nih.gov/pubmed/34202573
http://dx.doi.org/10.3390/v13071221
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