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Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines
Background: Lung-transplant (LT) recipients are at high risk for COVID-19 due to immunosuppression and respiratory tropism of SARS-CoV-2. The information on the effect of COVID-19 mRNA vaccines to elicit immunogenic responses after a two-dose (2D) regimen in LT recipients is sparse. Thus, we assesse...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310345/ https://www.ncbi.nlm.nih.gov/pubmed/34208884 http://dx.doi.org/10.3390/vaccines9070708 |
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author | Narasimhan, Madhusudhanan Mahimainathan, Lenin Clark, Andrew E Usmani, Amena Cao, Jing Araj, Ellen Torres, Fernando Sarode, Ravi Kaza, Vaidehi Lacelle, Chantale Muthukumar, Alagarraju |
author_facet | Narasimhan, Madhusudhanan Mahimainathan, Lenin Clark, Andrew E Usmani, Amena Cao, Jing Araj, Ellen Torres, Fernando Sarode, Ravi Kaza, Vaidehi Lacelle, Chantale Muthukumar, Alagarraju |
author_sort | Narasimhan, Madhusudhanan |
collection | PubMed |
description | Background: Lung-transplant (LT) recipients are at high risk for COVID-19 due to immunosuppression and respiratory tropism of SARS-CoV-2. The information on the effect of COVID-19 mRNA vaccines to elicit immunogenic responses after a two-dose (2D) regimen in LT recipients is sparse. Thus, we assessed the effect of Pfizer-BioNTech and Moderna mRNA vaccines’ 2D regimen on anti-spike responses in immunocompromised LT recipients. Methods: We utilized serum samples from LT recipients vaccinated for SARS-CoV-2 with 2D of either the Pfizer-BioNTech or Moderna vaccines and 2D-vaccinated naïve (non-transplanted and non-exposed to COVID-19) group. Antibody responses were assessed using the FDA-approved SARS-CoV-2 anti-nucleocapsid protein IgG assay (IgG(NC)), the SARS-CoV-2 anti-spike protein IgM assay (IgM(SP)), and the SARS-CoV-2 anti-spike protein IgG II assay (IgG(SP)). CD4+ T-cell activity was assessed as a marker of immune competence using the ImmuKnow(®) assay. Results: About 25% (18/73) of SARS-CoV-2 uninfected-LT patients generated a positive spike-IgG response following 2D of vaccines, with 36% (9/25) in the Moderna cohort and only 19% (9/48) in the Pfizer cohort. 2D in LT patients elicited a significantly lesser median IgG(SP) response (1.7 AU/mL, 95% CI: 0.6–7.5 AU/mL) compared to non-transplanted, uninfected naïve subjects (14,209 AU/mL, 95% CI: 11,261–18,836 AU/mL; p < 0.0001). In LT patients, the Moderna-evoked seropositivity trend was higher than Pfizer. Conclusion: 2D COVID-19 vaccination elicits a dampened serological response in LT patients. Whether assessing other arms of host immunity combined with a higher vaccine dose can better capture and elicit improved immunogenicity in this immunocompromised population warrants investigation. |
format | Online Article Text |
id | pubmed-8310345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83103452021-07-25 Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines Narasimhan, Madhusudhanan Mahimainathan, Lenin Clark, Andrew E Usmani, Amena Cao, Jing Araj, Ellen Torres, Fernando Sarode, Ravi Kaza, Vaidehi Lacelle, Chantale Muthukumar, Alagarraju Vaccines (Basel) Communication Background: Lung-transplant (LT) recipients are at high risk for COVID-19 due to immunosuppression and respiratory tropism of SARS-CoV-2. The information on the effect of COVID-19 mRNA vaccines to elicit immunogenic responses after a two-dose (2D) regimen in LT recipients is sparse. Thus, we assessed the effect of Pfizer-BioNTech and Moderna mRNA vaccines’ 2D regimen on anti-spike responses in immunocompromised LT recipients. Methods: We utilized serum samples from LT recipients vaccinated for SARS-CoV-2 with 2D of either the Pfizer-BioNTech or Moderna vaccines and 2D-vaccinated naïve (non-transplanted and non-exposed to COVID-19) group. Antibody responses were assessed using the FDA-approved SARS-CoV-2 anti-nucleocapsid protein IgG assay (IgG(NC)), the SARS-CoV-2 anti-spike protein IgM assay (IgM(SP)), and the SARS-CoV-2 anti-spike protein IgG II assay (IgG(SP)). CD4+ T-cell activity was assessed as a marker of immune competence using the ImmuKnow(®) assay. Results: About 25% (18/73) of SARS-CoV-2 uninfected-LT patients generated a positive spike-IgG response following 2D of vaccines, with 36% (9/25) in the Moderna cohort and only 19% (9/48) in the Pfizer cohort. 2D in LT patients elicited a significantly lesser median IgG(SP) response (1.7 AU/mL, 95% CI: 0.6–7.5 AU/mL) compared to non-transplanted, uninfected naïve subjects (14,209 AU/mL, 95% CI: 11,261–18,836 AU/mL; p < 0.0001). In LT patients, the Moderna-evoked seropositivity trend was higher than Pfizer. Conclusion: 2D COVID-19 vaccination elicits a dampened serological response in LT patients. Whether assessing other arms of host immunity combined with a higher vaccine dose can better capture and elicit improved immunogenicity in this immunocompromised population warrants investigation. MDPI 2021-06-30 /pmc/articles/PMC8310345/ /pubmed/34208884 http://dx.doi.org/10.3390/vaccines9070708 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Narasimhan, Madhusudhanan Mahimainathan, Lenin Clark, Andrew E Usmani, Amena Cao, Jing Araj, Ellen Torres, Fernando Sarode, Ravi Kaza, Vaidehi Lacelle, Chantale Muthukumar, Alagarraju Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title | Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title_full | Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title_fullStr | Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title_full_unstemmed | Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title_short | Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines |
title_sort | serological response in lung transplant recipients after two doses of sars-cov-2 mrna vaccines |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310345/ https://www.ncbi.nlm.nih.gov/pubmed/34208884 http://dx.doi.org/10.3390/vaccines9070708 |
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