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Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases
Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310350/ https://www.ncbi.nlm.nih.gov/pubmed/34357928 http://dx.doi.org/10.3390/vetsci8070136 |
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author | Grassinger, Julia Maria Floren, Andreas Müller, Tobias Cerezo-Echevarria, Argiñe Beitzinger, Christoph Conrad, David Törner, Katrin Staudacher, Marlies Aupperle-Lellbach, Heike |
author_facet | Grassinger, Julia Maria Floren, Andreas Müller, Tobias Cerezo-Echevarria, Argiñe Beitzinger, Christoph Conrad, David Törner, Katrin Staudacher, Marlies Aupperle-Lellbach, Heike |
author_sort | Grassinger, Julia Maria |
collection | PubMed |
description | Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = −2.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = −2.17), Jack Russell Terriers (log OR = −1.88), and Rhodesian Ridgebacks (log OR = −1.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or “resistance” to the development of specific acral tumors and/or other sites. |
format | Online Article Text |
id | pubmed-8310350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83103502021-07-25 Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases Grassinger, Julia Maria Floren, Andreas Müller, Tobias Cerezo-Echevarria, Argiñe Beitzinger, Christoph Conrad, David Törner, Katrin Staudacher, Marlies Aupperle-Lellbach, Heike Vet Sci Article Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = −2.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = −2.17), Jack Russell Terriers (log OR = −1.88), and Rhodesian Ridgebacks (log OR = −1.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or “resistance” to the development of specific acral tumors and/or other sites. MDPI 2021-07-17 /pmc/articles/PMC8310350/ /pubmed/34357928 http://dx.doi.org/10.3390/vetsci8070136 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grassinger, Julia Maria Floren, Andreas Müller, Tobias Cerezo-Echevarria, Argiñe Beitzinger, Christoph Conrad, David Törner, Katrin Staudacher, Marlies Aupperle-Lellbach, Heike Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title | Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title_full | Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title_fullStr | Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title_full_unstemmed | Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title_short | Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases |
title_sort | digital lesions in dogs: a statistical breed analysis of 2912 cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310350/ https://www.ncbi.nlm.nih.gov/pubmed/34357928 http://dx.doi.org/10.3390/vetsci8070136 |
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