Cargando…

Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia

Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of...

Descripción completa

Detalles Bibliográficos
Autores principales: Alhabbab, Rowa Y., Alsaieedi, Ahdab, Algaissi, Abdullah, Almahboub, Sara, Al-Raddadi, Rajaa M., Shabouni, Omaima I., Alhabbab, Rahaf, Alfaraj, Abdulelah A., Alamri, Sawsan S., Aljehani, Najwa D., Abdulal, Rwaa H., Alfaleh, Mohamed A., Abujamel, Turki S., Alkayyal, Almohanad A., Mahmoud, Ahmad Bakur, Abuzenadah, Adel M., Hashem, Anwar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310370/
https://www.ncbi.nlm.nih.gov/pubmed/34372618
http://dx.doi.org/10.3390/v13071413
_version_ 1783728745171910656
author Alhabbab, Rowa Y.
Alsaieedi, Ahdab
Algaissi, Abdullah
Almahboub, Sara
Al-Raddadi, Rajaa M.
Shabouni, Omaima I.
Alhabbab, Rahaf
Alfaraj, Abdulelah A.
Alamri, Sawsan S.
Aljehani, Najwa D.
Abdulal, Rwaa H.
Alfaleh, Mohamed A.
Abujamel, Turki S.
Alkayyal, Almohanad A.
Mahmoud, Ahmad Bakur
Abuzenadah, Adel M.
Hashem, Anwar M.
author_facet Alhabbab, Rowa Y.
Alsaieedi, Ahdab
Algaissi, Abdullah
Almahboub, Sara
Al-Raddadi, Rajaa M.
Shabouni, Omaima I.
Alhabbab, Rahaf
Alfaraj, Abdulelah A.
Alamri, Sawsan S.
Aljehani, Najwa D.
Abdulal, Rwaa H.
Alfaleh, Mohamed A.
Abujamel, Turki S.
Alkayyal, Almohanad A.
Mahmoud, Ahmad Bakur
Abuzenadah, Adel M.
Hashem, Anwar M.
author_sort Alhabbab, Rowa Y.
collection PubMed
description Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy.
format Online
Article
Text
id pubmed-8310370
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83103702021-07-25 Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia Alhabbab, Rowa Y. Alsaieedi, Ahdab Algaissi, Abdullah Almahboub, Sara Al-Raddadi, Rajaa M. Shabouni, Omaima I. Alhabbab, Rahaf Alfaraj, Abdulelah A. Alamri, Sawsan S. Aljehani, Najwa D. Abdulal, Rwaa H. Alfaleh, Mohamed A. Abujamel, Turki S. Alkayyal, Almohanad A. Mahmoud, Ahmad Bakur Abuzenadah, Adel M. Hashem, Anwar M. Viruses Article Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy. MDPI 2021-07-20 /pmc/articles/PMC8310370/ /pubmed/34372618 http://dx.doi.org/10.3390/v13071413 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alhabbab, Rowa Y.
Alsaieedi, Ahdab
Algaissi, Abdullah
Almahboub, Sara
Al-Raddadi, Rajaa M.
Shabouni, Omaima I.
Alhabbab, Rahaf
Alfaraj, Abdulelah A.
Alamri, Sawsan S.
Aljehani, Najwa D.
Abdulal, Rwaa H.
Alfaleh, Mohamed A.
Abujamel, Turki S.
Alkayyal, Almohanad A.
Mahmoud, Ahmad Bakur
Abuzenadah, Adel M.
Hashem, Anwar M.
Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title_full Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title_fullStr Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title_full_unstemmed Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title_short Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
title_sort seroprevalence of sars-cov-2 binding and neutralizing antibodies in healthcare workers during the epidemic peak in referral hospitals and quarantine sites: saudi arabia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310370/
https://www.ncbi.nlm.nih.gov/pubmed/34372618
http://dx.doi.org/10.3390/v13071413
work_keys_str_mv AT alhabbabroway seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alsaieediahdab seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT algaissiabdullah seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT almahboubsara seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alraddadirajaam seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT shabouniomaimai seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alhabbabrahaf seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alfarajabdulelaha seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alamrisawsans seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT aljehaninajwad seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT abdulalrwaah seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alfalehmohameda seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT abujamelturkis seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT alkayyalalmohanada seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT mahmoudahmadbakur seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT abuzenadahadelm seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia
AT hashemanwarm seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia