Cargando…
Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310370/ https://www.ncbi.nlm.nih.gov/pubmed/34372618 http://dx.doi.org/10.3390/v13071413 |
_version_ | 1783728745171910656 |
---|---|
author | Alhabbab, Rowa Y. Alsaieedi, Ahdab Algaissi, Abdullah Almahboub, Sara Al-Raddadi, Rajaa M. Shabouni, Omaima I. Alhabbab, Rahaf Alfaraj, Abdulelah A. Alamri, Sawsan S. Aljehani, Najwa D. Abdulal, Rwaa H. Alfaleh, Mohamed A. Abujamel, Turki S. Alkayyal, Almohanad A. Mahmoud, Ahmad Bakur Abuzenadah, Adel M. Hashem, Anwar M. |
author_facet | Alhabbab, Rowa Y. Alsaieedi, Ahdab Algaissi, Abdullah Almahboub, Sara Al-Raddadi, Rajaa M. Shabouni, Omaima I. Alhabbab, Rahaf Alfaraj, Abdulelah A. Alamri, Sawsan S. Aljehani, Najwa D. Abdulal, Rwaa H. Alfaleh, Mohamed A. Abujamel, Turki S. Alkayyal, Almohanad A. Mahmoud, Ahmad Bakur Abuzenadah, Adel M. Hashem, Anwar M. |
author_sort | Alhabbab, Rowa Y. |
collection | PubMed |
description | Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy. |
format | Online Article Text |
id | pubmed-8310370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83103702021-07-25 Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia Alhabbab, Rowa Y. Alsaieedi, Ahdab Algaissi, Abdullah Almahboub, Sara Al-Raddadi, Rajaa M. Shabouni, Omaima I. Alhabbab, Rahaf Alfaraj, Abdulelah A. Alamri, Sawsan S. Aljehani, Najwa D. Abdulal, Rwaa H. Alfaleh, Mohamed A. Abujamel, Turki S. Alkayyal, Almohanad A. Mahmoud, Ahmad Bakur Abuzenadah, Adel M. Hashem, Anwar M. Viruses Article Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy. MDPI 2021-07-20 /pmc/articles/PMC8310370/ /pubmed/34372618 http://dx.doi.org/10.3390/v13071413 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alhabbab, Rowa Y. Alsaieedi, Ahdab Algaissi, Abdullah Almahboub, Sara Al-Raddadi, Rajaa M. Shabouni, Omaima I. Alhabbab, Rahaf Alfaraj, Abdulelah A. Alamri, Sawsan S. Aljehani, Najwa D. Abdulal, Rwaa H. Alfaleh, Mohamed A. Abujamel, Turki S. Alkayyal, Almohanad A. Mahmoud, Ahmad Bakur Abuzenadah, Adel M. Hashem, Anwar M. Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title_full | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title_fullStr | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title_full_unstemmed | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title_short | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
title_sort | seroprevalence of sars-cov-2 binding and neutralizing antibodies in healthcare workers during the epidemic peak in referral hospitals and quarantine sites: saudi arabia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310370/ https://www.ncbi.nlm.nih.gov/pubmed/34372618 http://dx.doi.org/10.3390/v13071413 |
work_keys_str_mv | AT alhabbabroway seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alsaieediahdab seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT algaissiabdullah seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT almahboubsara seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alraddadirajaam seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT shabouniomaimai seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alhabbabrahaf seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alfarajabdulelaha seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alamrisawsans seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT aljehaninajwad seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT abdulalrwaah seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alfalehmohameda seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT abujamelturkis seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT alkayyalalmohanada seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT mahmoudahmadbakur seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT abuzenadahadelm seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia AT hashemanwarm seroprevalenceofsarscov2bindingandneutralizingantibodiesinhealthcareworkersduringtheepidemicpeakinreferralhospitalsandquarantinesitessaudiarabia |