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Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response

BACKGROUND: Zinc finger proteins encompass one of the unique and large families of proteins with diversified biological functions in the human body. These proteins are primarily considered to be DNA binding transcription factors; however, owing to the diverse array of zinc-finger domains, they are a...

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Autores principales: Rakhra, Gurseen, Rakhra, Gurmeen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310398/
https://www.ncbi.nlm.nih.gov/pubmed/34304391
http://dx.doi.org/10.1007/s11033-021-06556-x
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author Rakhra, Gurseen
Rakhra, Gurmeen
author_facet Rakhra, Gurseen
Rakhra, Gurmeen
author_sort Rakhra, Gurseen
collection PubMed
description BACKGROUND: Zinc finger proteins encompass one of the unique and large families of proteins with diversified biological functions in the human body. These proteins are primarily considered to be DNA binding transcription factors; however, owing to the diverse array of zinc-finger domains, they are able to interact with molecules other than DNA like RNA, proteins, lipids and PAR (poly-ADP-ribose). Evidences from recent scientific studies have provided an insight into the potential functions of zinc finger proteins in immune system regulation both at the transcriptional and post transcriptional level. However, the mechanism and importance of zinc finger proteins in the regulation of immune response is not very well defined and understood. This review highlights in detail the importance of zinc finger proteins in the regulation of immune system at transcriptional and post transcriptional level. CONCLUSION: Different types of zinc finger proteins are involved in immune system regulation and their mechanism of regulation is discussed herewith.
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spelling pubmed-83103982021-07-26 Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response Rakhra, Gurseen Rakhra, Gurmeen Mol Biol Rep Review BACKGROUND: Zinc finger proteins encompass one of the unique and large families of proteins with diversified biological functions in the human body. These proteins are primarily considered to be DNA binding transcription factors; however, owing to the diverse array of zinc-finger domains, they are able to interact with molecules other than DNA like RNA, proteins, lipids and PAR (poly-ADP-ribose). Evidences from recent scientific studies have provided an insight into the potential functions of zinc finger proteins in immune system regulation both at the transcriptional and post transcriptional level. However, the mechanism and importance of zinc finger proteins in the regulation of immune response is not very well defined and understood. This review highlights in detail the importance of zinc finger proteins in the regulation of immune system at transcriptional and post transcriptional level. CONCLUSION: Different types of zinc finger proteins are involved in immune system regulation and their mechanism of regulation is discussed herewith. Springer Netherlands 2021-07-24 2021 /pmc/articles/PMC8310398/ /pubmed/34304391 http://dx.doi.org/10.1007/s11033-021-06556-x Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Rakhra, Gurseen
Rakhra, Gurmeen
Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title_full Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title_fullStr Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title_full_unstemmed Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title_short Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
title_sort zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310398/
https://www.ncbi.nlm.nih.gov/pubmed/34304391
http://dx.doi.org/10.1007/s11033-021-06556-x
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