The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters

To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transport...

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Autores principales: Castagna, Michela, Cinquetti, Raffaella, Verri, Tiziano, Vacca, Francesca, Giovanola, Matteo, Barca, Amilcare, Romanazzi, Tiziana, Roseti, Cristina, Galli, Alessandra, Bossi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
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Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310414/
https://www.ncbi.nlm.nih.gov/pubmed/34304372
http://dx.doi.org/10.1007/s11064-021-03410-1
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author Castagna, Michela
Cinquetti, Raffaella
Verri, Tiziano
Vacca, Francesca
Giovanola, Matteo
Barca, Amilcare
Romanazzi, Tiziana
Roseti, Cristina
Galli, Alessandra
Bossi, Elena
author_facet Castagna, Michela
Cinquetti, Raffaella
Verri, Tiziano
Vacca, Francesca
Giovanola, Matteo
Barca, Amilcare
Romanazzi, Tiziana
Roseti, Cristina
Galli, Alessandra
Bossi, Elena
author_sort Castagna, Michela
collection PubMed
description To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11064-021-03410-1.
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spelling pubmed-83104142021-07-26 The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters Castagna, Michela Cinquetti, Raffaella Verri, Tiziano Vacca, Francesca Giovanola, Matteo Barca, Amilcare Romanazzi, Tiziana Roseti, Cristina Galli, Alessandra Bossi, Elena Neurochem Res Original Paper To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11064-021-03410-1. Springer US 2021-07-24 2022 /pmc/articles/PMC8310414/ /pubmed/34304372 http://dx.doi.org/10.1007/s11064-021-03410-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Castagna, Michela
Cinquetti, Raffaella
Verri, Tiziano
Vacca, Francesca
Giovanola, Matteo
Barca, Amilcare
Romanazzi, Tiziana
Roseti, Cristina
Galli, Alessandra
Bossi, Elena
The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title_full The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title_fullStr The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title_full_unstemmed The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title_short The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
title_sort lepidopteran kaat1 and caatch1: orthologs to understand structure–function relationships in mammalian slc6 transporters
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310414/
https://www.ncbi.nlm.nih.gov/pubmed/34304372
http://dx.doi.org/10.1007/s11064-021-03410-1
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