Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis

The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports t...

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Autores principales: Sicignano, Ludovico Luca, Massaro, Maria Grazia, Savino, Marinica, Rigante, Donato, Gerardino, Laura, Manna, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Letter to the editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310493/
https://www.ncbi.nlm.nih.gov/pubmed/33475973
http://dx.doi.org/10.1007/s11739-020-02627-2
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author Sicignano, Ludovico Luca
Massaro, Maria Grazia
Savino, Marinica
Rigante, Donato
Gerardino, Laura
Manna, Raffaele
author_facet Sicignano, Ludovico Luca
Massaro, Maria Grazia
Savino, Marinica
Rigante, Donato
Gerardino, Laura
Manna, Raffaele
author_sort Sicignano, Ludovico Luca
collection PubMed
description The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.
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spelling pubmed-83104932021-07-27 Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis Sicignano, Ludovico Luca Massaro, Maria Grazia Savino, Marinica Rigante, Donato Gerardino, Laura Manna, Raffaele Intern Emerg Med Research Letter to the editor The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy. Springer International Publishing 2021-01-21 2021 /pmc/articles/PMC8310493/ /pubmed/33475973 http://dx.doi.org/10.1007/s11739-020-02627-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Letter to the editor
Sicignano, Ludovico Luca
Massaro, Maria Grazia
Savino, Marinica
Rigante, Donato
Gerardino, Laura
Manna, Raffaele
Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title_full Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title_fullStr Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title_full_unstemmed Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title_short Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
title_sort early introduction of anakinra improves acute pericarditis and prevents tamponade in staphylococcal sepsis
topic Research Letter to the editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310493/
https://www.ncbi.nlm.nih.gov/pubmed/33475973
http://dx.doi.org/10.1007/s11739-020-02627-2
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