Progranulin deficiency in Iba-1(+) myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation

BACKGROUND: Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and...

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Detalles Bibliográficos
Autores principales: Takahashi, Kei, Nakamura, Shinsuke, Otsu, Wataru, Shimazawa, Masamitsu, Hara, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310601/
https://www.ncbi.nlm.nih.gov/pubmed/34304733
http://dx.doi.org/10.1186/s12974-021-02203-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310601/
https://www.ncbi.nlm.nih.gov/pubmed/34304733
http://dx.doi.org/10.1186/s12974-021-02203-1

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