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Progranulin deficiency in Iba-1(+) myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
BACKGROUND: Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310601/ https://www.ncbi.nlm.nih.gov/pubmed/34304733 http://dx.doi.org/10.1186/s12974-021-02203-1 |