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Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease

Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefor...

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Autores principales: Eskandari, Mahsa, Awsat Mellati, Ali, Mahmoodi, Khalil, Kamali, Koorosh, Soltanpour, Mohammad Soleiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310655/
https://www.ncbi.nlm.nih.gov/pubmed/34316491
http://dx.doi.org/10.22099/mbrc.2021.39141.1574
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author Eskandari, Mahsa
Awsat Mellati, Ali
Mahmoodi, Khalil
Kamali, Koorosh
Soltanpour, Mohammad Soleiman
author_facet Eskandari, Mahsa
Awsat Mellati, Ali
Mahmoodi, Khalil
Kamali, Koorosh
Soltanpour, Mohammad Soleiman
author_sort Eskandari, Mahsa
collection PubMed
description Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, P<0.001) was significantly associated with CAD risk. Further analysis identified CYP1A1 rs4646903 polymorphism as a significant risk factor for early onset (P= 0.005) but not late onset (P=0.066) CAD. However, the frequency of heterozygous and homozygous mutant genotype of rs4646903 polymorphism did not differ significantly among the CAD patients with various number of stenotic vessel (P>0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD.
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spelling pubmed-83106552021-07-26 Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease Eskandari, Mahsa Awsat Mellati, Ali Mahmoodi, Khalil Kamali, Koorosh Soltanpour, Mohammad Soleiman Mol Biol Res Commun Original Article Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, P<0.001) was significantly associated with CAD risk. Further analysis identified CYP1A1 rs4646903 polymorphism as a significant risk factor for early onset (P= 0.005) but not late onset (P=0.066) CAD. However, the frequency of heterozygous and homozygous mutant genotype of rs4646903 polymorphism did not differ significantly among the CAD patients with various number of stenotic vessel (P>0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD. Shiraz University 2021-06 /pmc/articles/PMC8310655/ /pubmed/34316491 http://dx.doi.org/10.22099/mbrc.2021.39141.1574 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Eskandari, Mahsa
Awsat Mellati, Ali
Mahmoodi, Khalil
Kamali, Koorosh
Soltanpour, Mohammad Soleiman
Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title_full Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title_fullStr Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title_full_unstemmed Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title_short Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
title_sort association of the cyp1a1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310655/
https://www.ncbi.nlm.nih.gov/pubmed/34316491
http://dx.doi.org/10.22099/mbrc.2021.39141.1574
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