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Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease
Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Shiraz University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310655/ https://www.ncbi.nlm.nih.gov/pubmed/34316491 http://dx.doi.org/10.22099/mbrc.2021.39141.1574 |
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author | Eskandari, Mahsa Awsat Mellati, Ali Mahmoodi, Khalil Kamali, Koorosh Soltanpour, Mohammad Soleiman |
author_facet | Eskandari, Mahsa Awsat Mellati, Ali Mahmoodi, Khalil Kamali, Koorosh Soltanpour, Mohammad Soleiman |
author_sort | Eskandari, Mahsa |
collection | PubMed |
description | Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, P<0.001) was significantly associated with CAD risk. Further analysis identified CYP1A1 rs4646903 polymorphism as a significant risk factor for early onset (P= 0.005) but not late onset (P=0.066) CAD. However, the frequency of heterozygous and homozygous mutant genotype of rs4646903 polymorphism did not differ significantly among the CAD patients with various number of stenotic vessel (P>0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD. |
format | Online Article Text |
id | pubmed-8310655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Shiraz University |
record_format | MEDLINE/PubMed |
spelling | pubmed-83106552021-07-26 Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease Eskandari, Mahsa Awsat Mellati, Ali Mahmoodi, Khalil Kamali, Koorosh Soltanpour, Mohammad Soleiman Mol Biol Res Commun Original Article Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, P<0.001) was significantly associated with CAD risk. Further analysis identified CYP1A1 rs4646903 polymorphism as a significant risk factor for early onset (P= 0.005) but not late onset (P=0.066) CAD. However, the frequency of heterozygous and homozygous mutant genotype of rs4646903 polymorphism did not differ significantly among the CAD patients with various number of stenotic vessel (P>0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD. Shiraz University 2021-06 /pmc/articles/PMC8310655/ /pubmed/34316491 http://dx.doi.org/10.22099/mbrc.2021.39141.1574 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Eskandari, Mahsa Awsat Mellati, Ali Mahmoodi, Khalil Kamali, Koorosh Soltanpour, Mohammad Soleiman Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title | Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title_full | Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title_fullStr | Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title_full_unstemmed | Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title_short | Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
title_sort | association of the cyp1a1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310655/ https://www.ncbi.nlm.nih.gov/pubmed/34316491 http://dx.doi.org/10.22099/mbrc.2021.39141.1574 |
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